Well: Expressing the Inexpressible

When Kyle Potvin learned she had breast cancer at the age of 41, she tracked the details of her illness and treatment in a journal. But when it came to grappling with issues of mortality, fear and hope, she found that her best outlet was poetry.

How I feared chemo, afraid
It would change me.
It did.
Something dissolved inside me.
Tears began a slow drip;
I cried at the news story
Of a lost boy found in the woods …
At the surprising beauty
Of a bright leaf falling
Like the last strand of hair from my head

Ms. Potvin, now 47 and living in Derry, N.H., recently published “Sound Travels on Water” (Finishing Line Press), a collection of poems about her experience with cancer. And she has organized the Prickly Pear Poetry Project, a series of workshops for cancer patients.

“The creative process can be really healing,” Ms. Potvin said in an interview. “Loss, mortality and even hopefulness were on my mind, and I found that through writing poetry I was able to express some of those concepts in a way that helped me process what I was thinking.”

In April, the National Association for Poetry Therapy, whose members include both medical doctors and therapists, is to hold a conference in Chicago with sessions on using poetry to manage pain and to help adolescents cope with bullying. And this spring, Tasora Books will publish “The Cancer Poetry Project 2,” an anthology of poems written by patients and their loved ones.

Dr. Rafael Campo, an associate professor of medicine at Harvard, says he uses poetry in his practice, offering therapy groups and including poems with the medical forms and educational materials he gives his patients.

“It’s always striking to me how they want to talk about the poems the next time we meet and not the other stuff I give them,” he said. “It’s such a visceral mode of expression. When our bodies betray us in such a profound way, it can be all the more powerful for patients to really use the rhythms of poetry to make sense of what is happening in their bodies.”

On return visits, Dr. Campo’s patients often begin by discussing a poem he gave them — for example, “At the Cancer Clinic,” by Ted Kooser, from his collection “Delights & Shadows” (Copper Canyon Press, 2004), about a nurse holding the door for a slow-moving patient.

How patient she is in the crisp white sails
of her clothes. The sick woman
peers from under her funny knit cap
to watch each foot swing scuffing forward
and take its turn under her weight.
There is no restlessness or impatience
or anger anywhere in sight. Grace
fills the clean mold of this moment
and all the shuffling magazines grow still.

In Ms. Potvin’s case, poems related to her illness were often spurred by mundane moments, like seeing a neighbor out for a nightly walk. Here is “Tumor”:

My neighbor walks
For miles each night.
A mantra drives her, I imagine
As my boys’ chant did
The summer of my own illness:
“Push, Mommy, push.”
Urging me to wind my sore feet
Winch-like on a rented bike
To inch us home.
I couldn’t stop;
Couldn’t leave us
Miles from the end.

Karin Miller, 48, of Minneapolis, turned to poetry 15 years ago when her husband developed testicular cancer at the same time she was pregnant with their first child.

Her husband has since recovered, and Ms. Miller has reviewed thousands of poems by cancer patients and their loved ones to create the “Cancer Poetry Project” anthologies. One poem is “Hymn to a Lost Breast,” by Bonnie Maurer.

Oh let it fly
let it fling
let it flip like a pancake in the air
let it sing: what is the song
of one breast flapping?

Another is “Barn Wish” by Kim Knedler Hewett.

I sit where you can’t see me
Listening to the rustle of papers and pills in the other room,
Wondering if you can hear them.
Let’s go back to the barn, I whisper.
Let’s turn on the TV and watch the Bengals lose.
Let’s eat Bill’s Doughnuts and drink Pepsi.
Anything but this.

Ms. Miller has asked many of her poets to explain why they find poetry healing. “They say it’s the thing that lets them get to the core of how they are feeling,” she said. “It’s the simplicity of poetry, the bare bones of it, that helps them deal with their fears.”


Have you written a poem about cancer? Please share them with us in the comments section below.
Read More..

DealBook: Dell Nears a Buyout Deal of More Than $23 Billion

Dell Inc. neared an agreement on Monday to sell itself to a group led by its founder and the investment firm Silver Lake for more than $23 billion, people briefed on the matter said, in what would be the biggest buyout since the financial crisis.

If completed, a takeover would be the most ambitious attempt yet by Michael S. Dell to revive the company that bears his name. Such is the size of the potential deal that Mr. Dell has called upon Microsoft, one of his most important business partners, to shore up the proposal with additional financial muscle. The question will now turn to whether taking the personal computer maker private will accomplish what years of previous turnaround efforts have not.

The final details were being negotiated on Monday evening, and a deal could be announced as soon as Tuesday. Still, last-minute obstacles could cause the talks to collapse, the people briefed on the matter cautioned.

The consortium is expected to pay $13.50 to $13.75 a share, these people said. Mr. Dell is expected to contribute his nearly 16 percent stake to the deal, worth about $3.8 billion under the current set of terms. He is also expected to contribute hundreds of millions of dollars in fresh capital from his own fortune.

Silver Lake, known as one of the biggest investors in technology companies, would most likely contribute roughly $1 billion, these people added. Microsoft is expected to put in about $2 billion, though that would probably come in the form of preferred shares or debt.

Dell is also expected to bring home some of the cash that it holds in offshore accounts to help with the financing.

A spokesman for Dell declined to comment.

For decades, Dell benefited from its status as a pioneer in the market for personal computers. Founded in 1984 in a dormitory room at the University of Texas, the company grew into one of the biggest computer makers in the world, built on the simple premise that customers would flock to customize their machines.

By the late 1990s, its fast-rising stock created a company worth $100 billion and minted a class of “Dellionaires” whose holdings made for big fortunes, at least on paper. Mr. Dell amassed an estimated $16 billion and formed a quietly powerful investment firm to manage those riches.

But growing competition has sapped Dell’s strength. Rivals like Lenovo and Samsung have made the PC-making business less profitable. Last month, the market research firm Gartner reported that Dell sold 37.6 million PCs worldwide in 2012, a 12.3 percent drop from the previous year’s shipments. Perhaps more significant is the emergence of the smartphone and the tablet, two classes of devices that have eaten away at sales of traditional computers.

Mr. Dell has sought to move the company into the more lucrative and stable business of providing corporations with software services, spending billions of dollars on acquisitions to lead that transformation. The aim is to refashion Dell into something more like I.B.M. or Oracle. Even so, manufacturing PCs still makes up half of the company’s business.

The company’s stock had fallen 59 percent in the 10 years ended Jan. 11, the last business day before word of the buyout talks emerged. That has actually made Dell more tempting as a takeover target for its founder and Silver Lake, which see it as undervalued.

A Dell deal would be a watershed moment for the leveraged buyout industry: It would be the largest takeover since the Blackstone Group paid $26 billion for Hilton Hotels in the summer of 2007. No leveraged buyout since the financial crisis has surpassed the $7.2 billion that Kohlberg Kravis Roberts and others paid for the Samson Investment Company, an oil and gas driller, in the fall of 2011.

Private equity executives have hungered for the chance to strike a deal worth more than $10 billion, an accomplishment believed difficult because of the sheer size of financing required. Dell would take on more than $15 billion in debt, an enormous amount arranged by no fewer than four banks.

But the debt markets have been soaring over the last two years, as the cost of junk bonds has stayed low. Persistent low interest rates have prompted debt buyers to seek investments that carry higher yields

Dell was unusually well-placed to make a deal with private equity. The company carries $4.9 billion in long-term debt, which some analysts have regarded as a manageable amount. And its management has signaled a willingness to bring back at least some of the company’s cash hoard held overseas, despite potentially ringing up a hefty tax bill.

It is unclear whether the company’s biggest investors will accept a deal at the levels that the buyer consortium is advocating. Shares of Dell fell 2.6 percent, to $13.27, on Monday after reports of the proposed price range emerged.

Biggest Private Equity-Backed Leveraged Buyouts

DEAL, IN BILLIONSTARGETBUYERANNOUNCED
Source: Thomson Reuters *At time of deal, including assumption of debt, not adjusted for inflation.
$44.3TXUMorgan Stanley, Citigroup, Lehman Brothers Holdings, Kohlberg Kravis Roberts, Texas Pacific Group and Goldman SachsFebruary 2007
37.7Equity Office Properties TrustBlackstone GroupNovember 2006
32.1HCABain Capital, Kohlberg Kravis Roberts and Merrill Lynch Global PrivateJuly 2006
30.2RJR NabiscoKohlberg Kravis RobertsOctober 1988
30.1BAAGrupo Ferrovial SA, Caisse de Depot et Placement and GIC Special InvestMarch 2006
27.6Harrah’s EntertainmentTexas Pacific Group and Apollo ManagementOctober 2006
27.4Kinder MorganGS Capital Partners, The Carlyle Group and Riverstone HoldingsMay 2006
27.2AlltelTPG Capital and GS Capital PartnersMay 2007
27.0First DataKohlberg Kravis RobertsApril 2007
26.7Hilton HotelsBlackstone GroupJuly 2007
Read More..

India Ink: 'Lalla Roukh' at the Rose Theater


Richard Termine for The New York Times


Lalla Roukh Marianne Fiset and Emiliano Gonzalez Toro starred in this work presented by Opera Lafayette on Thursday at the Rose Theater.







On Thursday evening Opera Lafayette presented a graceful and witty production of Félicien David’s “Lalla Roukh” at the Rose Theater. This opéra-comique set in Mughal India had fallen into oblivion since its wildly successful premiere in 1862, well ahead of the wave of other French operas like Bizet’s “Pêcheurs de Perles,” Delibes’s “Lakmé” or Meyerbeer’s “Africaine.”




Operas like these, in which the West’s flirtation with distant locales is colored with condescension, can bring on a toothache in the stage director who has to choose between an unreconstructed eye-candy approach or a Splenda version that leaves an aftertaste of postcolonial embarrassment.


Here the director, Bernard Deletré, devised an unusual solution when he brought in an Indian fashion designer, Poonam Bhagat, and the exquisite Kalanidhi dance troupe choreographed by Anuradha Nehru to add vibrant touches of authenticity to the dress and movement of characters who otherwise seem less rooted in South Asia than in commedia dell’arte. The spoken dialogue was edited down to its dramatic essentials and delivered with great clarity by the glowing cast of singers, most of whom were native French speakers. Together with Ryan Brown, who conducted with a fine ear for flow and comic timing, they made a solid case for “Lalla Roukh” as an overlooked gem of more than historical interest.


The heroine is a princess from Delhi who travels to Bukhara to marry its king. On a mountain pass in Kashmir she is waylaid by a silver-tongued poet with whom she falls in love. She arrives at the court determined to throw over the royal match in favor of the penniless poet, but it turns out that he was in fact the king disguised to test Lalla Roukh’s heart.


The opera contains exquisite musical moments, like the ballet in Act I in which the chorus evokes the starry sky reflected in a clear mountain lake with filigree woodwind solos against caressing choral lines. The following ballet of bayadères is carried by lively rhythms on an array of exotic percussion instruments, here joined by the ankle bells of the dancers.


Although David’s Orientalism is never authentic, it is still rich in naturalistic touches. As a young man he spent two years in Cairo and his familiarity with non-Western modes comes through in finely wrought oboe solos, alluring chromatic vocal lines and, in one aria, pizzicato passages meant to imitate the sound of a guzla.


Marianne Fiset sang the title role with a glowing, well-supported soprano that brought out the Jane Austen-like independence and likability of her character. The tenor Emiliano Gonzalez Toro was outstanding as the poet-king Noureddin, bringing a scintillating array of nuances to a character who is by turns comic, regal and wistful. The role of Lalla Roukh’s quick-witted maid, Mirza, was sung by Nathalie Paulin with a honeyed soprano. Mr. Deletré, the director, stepped into the buffoonish role of Baskir, the king’s chamberlain, with conviction and comic abandon.


Read More..

Is it game over for Nintendo?






The Wii U is a bust (so far). And the legendary gaming company’s future is looking increasingly bleak


Nintendo had no choice but to go all in with the Wii U, the newest in a long line of ostensibly childhood-defining game consoles. Unfortunately, the company also inherited the weighty expectations of the original Wii — which, if you’ll remember, became a surprise hit when it debuted in 2006, or just two short years after the world was first introduced to a little-known senator named Barack Obama. But ever since the Wii U hit store shelves last November, sales have been disappointing. Now the company is dramatically lowering its forecasts for the future. 






Initial sales figures indicate that Nintendo has so far sold just 3.06 million Wii U game consoles, and anticipates moving just four million Wii U units through March — far below previous estimates of 5.5 million, predictions that weren’t even that optimistic to begin with. 


Initial reviews of the Wii U were mixed. Yes, it’s fun. But the console failed to offer a compelling reason for consumers to free up dusty shelf space alongside their Xbox 360s or PlayStation 3s. Some critics say the console is confused, and Nintendo didn’t know if it was targeting mature gamers fixated on first-person shooter games like Call of Duty and Borderlands, or more casual fans like the original Wii did with its motion-sensing nunchuck. Further complicating matters is a nimble new mobile industry, dominated by non-committal, take-anywhere games like Temple Run and Angry Birds


“Nintendo needs a change in strategy,” Michael Pachter, a gaming research analyst for Wedbush Securities, tells The New York Times. Even though Nintendo is an instantly recognizable brand the world over, the company still doesn’t license its gaming titles for other platforms (ever see Mario on an iPhone?). To make matters worse, on Thursday, Nintendo president Satoru Iwata said that the company has no intention of lowering the price of its $ 300 flagship gaming system anytime soon. “We were already offering it at a good price,” he said. 


That means Nintendo, unless it releases a best-selling breakout title soon (Zelda, perhaps? Super Smash Bros. Brawl?), will continue on its path toward an increasingly dark future. The company already had its worst year ever in 2011. Dramatic restructuring seems imminent.


Consoles — compared to phones, tablets, laptops, and many other gadgets — have a much slower product cycle. Manufacturers only press “reset” every couple of years so that game-makers aren’t constantly readjusting to new hardware.


For quickly aging dinosaurs like Nintendo, that means more plodding along. More disappointing forecasts. More reluctant critics. More lost opportunities to earn the trust of lifelong fans. More, more, more. (Or for Nintendo, less, less, less?)


“People have to try it to see it is fun,” Iwata said of the Wii U. Undoubtedly, it is.


But unfortunately for Nintendo, “fun” just isn’t good enough anymore.


View this article on TheWeek.com Get 4 Free Issues of The Week


Other stories from this topic:


Like on Facebook - Follow on Twitter - Sign-up for Daily Newsletter
Gaming News Headlines – Yahoo! News





Title Post: Is it game over for Nintendo?
Url Post: http://www.news.fluser.com/is-it-game-over-for-nintendo/
Link To Post : Is it game over for Nintendo?
Rating:
100%

based on 99998 ratings.
5 user reviews.
Author: Fluser SeoLink
Thanks for visiting the blog, If any criticism and suggestions please leave a comment




Read More..

Lights out: Ravens beat 49ers 34-31 in Super Bowl


NEW ORLEANS (AP) — From blowout to blackout to shootout, Joe Flacco and the Baltimore Ravens had just enough power to survive one of the most electric Super Bowls ever.


The outage flipped the momentum to the San Francisco 49ers, but the Ravens used a last-gasp defensive stand to hold on Sunday night, 34-31.


America's biggest sporting event came to a half-hour standstill in the third quarter when most of the Superdome lights and the scoreboards went dark. By then, the Ravens had a 22-point lead.


Everything changed after that, though, and the 49ers staged a sensational rally before Ray Lewis and Co. shut it down. But there were plenty of white-knuckle moments and the Ravens (14-6) had to make four stops inside their 7 at the end.


For a Super Bowl with so many subplots, it almost had to end this way.


Flacco's arrival as a championship quarterback coincides with Lewis' retirement — with a second Super Bowl ring no less. The win capped a sensational month since the star linebacker announced he was leaving the game after 17 Hall of Fame-caliber years.


The sibling rivalry between the coaching Harbaughs went to John, older than Jim by 15 months.


"How could it be any other way? It's never pretty. It's never perfect. But it's us," John Harbaugh said. "It was us today."


At 4 hours, 14 minutes, it was the longest Super Bowl ever. Among the most thrilling, too.


The loss of power delayed the game 34 minutes and left players from both sides stretching and chatting with each other. It also cost Baltimore whatever momentum it built, and that was considerable after Jacoby Jones' 108-yard kickoff return and Flacco's three touchdown passes made it 28-6.


Flacco's big start boosted him to the MVP award.


"They have to give it to one guy and I'm not going to complain that I got it," said Flacco, who soon will get a rich new contract. His current deal expired with this win.


Down by three TDs, back came San Francisco (13-5-1) in search of its sixth Lombardi Trophy in as many tries.


Michael Crabtree's 31-yard touchdown reception on which he broke two tackles made it 28-13. A couple minutes later, Frank Gore's 6-yard run followed a 32-yard punt return by Ted Ginn Jr., and the 49ers were within eight.


Ray Rice's fumble at his 24 led to David Akers' 34-yard field goal, but Baltimore woke up for a long drive leading to rookie Justin Tucker's 19-yard field goal.


San Francisco wasn't done challenging, though, and Colin Kaepernick's 15-yard TD run, the longest for a quarterback in a Super Bowl, made it 31-29. A 2-point conversion pass failed when the Ravens blitzed.


Tucker added a 38-yarder with 4:19 remaining, setting up the frantic finish.


Kaepernick couldn't get the Ravens into the end zone on the final three plays — there was contact on Crabtree on the final pass that appeared incidental, and Jim Harbaugh insisted it was holding.


Ravens punter Sam Koch took a safety for the final score with 4 seconds left. His free kick was returned by Ginn to midfield as time ran out.


The Harbaughs then met at midfield amid the Ravens' confetti-laden celebrations.


"It's very tough," John Harbaugh said of their conversation. "It's a lot tougher than I thought it was going to be. It's very painful."


In the first half, Flacco was as brilliant as Tom Brady, Joe Montana or Terry Bradshaw ever were in the NFL's biggest game. The only quarterback to win a playoff game in each of his first five seasons — his coach holds the same distinction — was nearly perfect. Overall, Flacco threw for 11 touchdowns to tie a postseason record, and had no interceptions.


The Ravens stumbled into the playoffs with four defeats in its last five regular-season games as Lewis recovered from a torn right triceps and Flacco struggled. Harbaugh even fired his offensive coordinator in December, a stunning move with the postseason so close.


But that — and every other move Harbaugh, Flacco and the Ravens made since — were right on target. Just like Flacco's TD passes of 13 yards to Anquan Boldin, 1 to Dennis Pitta and 56 to Jones in the first half, tying a Super Bowl record.


New Orleans native Jones, one of the heroes in a double-overtime playoff win at Denver, seemed to put the game away with his record 108-yard sprint with the second-half kickoff.


Soon after, the lights went out — and when they came back on, the Ravens were almost powerless to slow the 49ers.


Until the final moments.


"The final series of Ray Lewis' career was a goal-line stand," Harbaugh said.


Lewis sprawled on all fours, face-down on the turf, after the end zone incompletion.


"It's no greater way, as a champ, to go out on your last ride with the men that I went out with, with my teammates," Lewis said. "And you looked around this stadium and Baltimore! Baltimore! We coming home, baby! We did it!"


It was a bitter loss for Jim Harbaugh, the coach who turned around the Niners in the last two years and brought them to their first Super Bowl in 18 years. His team made a similarly stunning comeback in the NFC championship at Atlanta, but couldn't finish it off against Baltimore.


"Our guys battled back to get back in," said the 49ers coach, who was especially upset about the non-call on the pass to Crabtree.


The 49ers couldn't have been sloppier in the first half, damaging their chances with penalties — including one on their first play that negated a 20-yard gain — poor tackling and turnovers. Rookie LaMichael James fumbled at the Baltimore 25 to ruin an impressive drive, and the Ravens converted that with Flacco's 1-yard pass to Pitta for a 14-3 lead.


On San Francisco's next offensive play, Kaepernick threw behind Randy Moss and always dependable safety Ed Reed picked it off. A huge scuffle followed that brought both Harbaughs onto the field and saw both sides penalized 15 yards for unnecessary roughness.


Reed, also a New Orleans native, tied the NFL record for postseason picks with his ninth.


Baltimore didn't pounce on that mistake for points. Instead, Tucker's fake field goal run on fourth-and-9 came up a yard short when Chris Culliver slammed him out of bounds.


The Ravens simply shrugged, forced a three-and-out, and then unleashed Jones deep. Just as he did to Denver, he flashed past the secondary and caught Flacco's fling. He had to wait for the ball, fell to the ground to grab it, but was untouched by a Niner. Up he sprang, cutting left and using his speed to outrun two defenders to the end zone.


Desperate for some points, the 49ers completed four passes and got a 15-yard roughing penalty against Haloti Ngata, who later left with a knee injury. But again they couldn't cross the goal line, Paul Kruger got his second sack of the half on third down, forcing a second Akers field goal, from 27 yards.


When Jones began the second half by sprinting up the middle virtually untouched — he is the second player with two TDs of 50 yards or more in a Super Bowl, tying Washington's Ricky Sanders in 1988 — the rout was on.


Then it wasn't.


The Ravens' thrilling victory provided a grand finale for the Big Easy, which hosted its first Super Bowl since 2002 and first since Hurricane Katrina ravaged the city. But it's been a tough year for local fans. A bounties scandal and resultant suspensions helped ruin the Saints' season almost before it began, making Commissioner Roger Goodell the city's Public Enemy No. 1.


The season also was marred by a lockout of the on-field officials that turned farcical when replacement refs couldn't handle the job.


Even Super Bowl week was disrupted by reports that deer-antler spray, of all things, might have been used by NFL players as a performance enhancer.


And then the NFL's showcase event was stopped cold by a lack of power.


Flacco, though, provided plenty of sizzle.


Read More..

Medicines Co. Licenses Rights to Cholesterol Drug



The drug, known as ALN-PCS, inhibits a protein in the body known as PCSK9. Such drugs might one day be used to treat millions of people who do not achieve sufficient cholesterol-lowering from commonly used statins, such as Lipitor.


The Medicines Company will pay $25 million initially and as much as $180 million later if certain development and sales goals are met, under the deal expected to be formally announced Monday. It will also pay Alnylam, which is based in Cambridge, Mass., double-digit royalties on global sales.


That is small payment for a drug with presumably a huge potential market, probably reflecting that Alnylam is still in the first of three phases of clinical trials, well behind some far bigger competitors.


The team of Sanofi and Regeneron Pharmaceuticals is already entering the third and final stage of trials with their PCSK9 inhibitor, as is Amgen. Pfizer and Roche are in midstage trials.


ALN-PCS is different from the other drugs. It uses a gene-silencing mechanism called RNA interference, aimed at shutting off production of the PCSK9 protein. The other drugs are proteins called monoclonal antibodies that inhibit the action of PCSK9 after it has been formed.


Alnylam and the Medicines Company hope that turning off the faucet, as it were, will be more efficient than mopping the floor, allowing their drug to be given less frequently and in smaller amounts.


But that has yet to be proved. No drug using RNA interference has reached the market.


The Medicines Company, based in Parsippany, N.J., generates almost all of its revenue from one product — Angiomax, an anticlotting drug used when patients receive stents to open clogged arteries.


Dr. Clive A. Meanwell, chief executive of the company, said that PCSK9 inhibitors are likely to be used at first mainly by patients with severe lipid problems under the care of interventional cardiologists, the same doctors who use Angiomax. “It really is quite adjacent to what we do,” he said.


The Medicines Company licensed Angiomax from Biogen Idec, where the drug was invented and initially developed under a team led by Dr. John M. Maraganore, who is now the chief executive of Alnylam.


“It’s a bit like getting the band back together,” Dr. Maraganore said.


Read More..

Medicines Co. Licenses Rights to Cholesterol Drug



The drug, known as ALN-PCS, inhibits a protein in the body known as PCSK9. Such drugs might one day be used to treat millions of people who do not achieve sufficient cholesterol-lowering from commonly used statins, such as Lipitor.


The Medicines Company will pay $25 million initially and as much as $180 million later if certain development and sales goals are met, under the deal expected to be formally announced Monday. It will also pay Alnylam, which is based in Cambridge, Mass., double-digit royalties on global sales.


That is small payment for a drug with presumably a huge potential market, probably reflecting that Alnylam is still in the first of three phases of clinical trials, well behind some far bigger competitors.


The team of Sanofi and Regeneron Pharmaceuticals is already entering the third and final stage of trials with their PCSK9 inhibitor, as is Amgen. Pfizer and Roche are in midstage trials.


ALN-PCS is different from the other drugs. It uses a gene-silencing mechanism called RNA interference, aimed at shutting off production of the PCSK9 protein. The other drugs are proteins called monoclonal antibodies that inhibit the action of PCSK9 after it has been formed.


Alnylam and the Medicines Company hope that turning off the faucet, as it were, will be more efficient than mopping the floor, allowing their drug to be given less frequently and in smaller amounts.


But that has yet to be proved. No drug using RNA interference has reached the market.


The Medicines Company, based in Parsippany, N.J., generates almost all of its revenue from one product — Angiomax, an anticlotting drug used when patients receive stents to open clogged arteries.


Dr. Clive A. Meanwell, chief executive of the company, said that PCSK9 inhibitors are likely to be used at first mainly by patients with severe lipid problems under the care of interventional cardiologists, the same doctors who use Angiomax. “It really is quite adjacent to what we do,” he said.


The Medicines Company licensed Angiomax from Biogen Idec, where the drug was invented and initially developed under a team led by Dr. John M. Maraganore, who is now the chief executive of Alnylam.


“It’s a bit like getting the band back together,” Dr. Maraganore said.


Read More..

Al-Qaida-Linked Militants Free 2 Filipino Hostages







MANILA, Philippines (AP) — Abu Sayyaf gunmen have freed two Filipino members of a Jordanian TV journalist's crew who were kidnapped by the al-Qaida-linked militants last year as they set out to interview the extremists in their jungle lairs in the southern Philippines, police said Sunday.




Policemen found frail-looking cameraman Ramel Vela and audio technician Roland Letriro late Saturday and brought them to a hospital in southern Sulu province, where they were kidnapped in June along with Jordanian Baker Abdulla Atyani, provincial police chief Senior Superintendent Antonio Freyra said.


Atyani is believed to still be held by the gunmen in the jungles of Sulu's mountainous Patikul town, about 950 kilometers (590 miles) south of Manila.


"We're so happy. We never thought we'd make it out alive," a teary-eyed Vela said at his hospital bed, adding that he and Letriro have not seen Atyani since the Jordanian was separated from them by their kidnappers five days after they were taken hostage.


Visibly thinner, shocked and with overgrown hair and beard, the two were examined by doctors and given bread and water in the Sulu hospital, which was guarded by police and marines.


"They really lost weight because they were constantly under stress each day," Freyra told The Associated Press.


An unspecified amount was paid to secure the freedom of the two captives, according to three security officials who have been closely monitoring the kidnappings. The three spoke on condition of anonymity because they were not authorized to talk to reporters.


Military officials have said Abu Sayyaf militants have demanded 130 million pesos ($3.1 million) for the release of Atyani and his two crew members.


Hundreds of rebels from the larger Moro National Liberation Front, which signed a 1996 autonomy deal with the government, have also been negotiating with the Abu Sayyaf for the release of Atyani and other foreign hostages, including two European bird watchers who were abducted last year.


Moro commander Khabir Malik said his group had taken the initiative to seek the freedom of the hostages to help the government clean up the image of Sulu, a predominantly Muslim province where the Abu Sayyaf has carried out deadly bombings, kidnappings for ransom and beheadings, primarily in the early 2000s.


U.S.-backed military offensives have crippled the Abu Sayyaf in recent years, but it remains a national security threat. Washington has listed the group as a terrorist organization.


Malik said last week that he met with an Abu Sayyaf commander, Jul-Asman Sawadjaan, to seek the release of Atyani and his two crew members, who were believed being held in the jungles of Sulu's mountainous Patikul town. But the extremists refused to release their captives to the Moro rebels, Malik said.


Malik had suggested that his armed group could consider other options, including a rescue, to secure the captives' freedom from the smaller Abu Sayyaf group.


Abu Sayyaf gunmen handed the two Filipinos to still-unknown negotiators, but not to Malik's group, angering the Moro rebels, according to the three security officials.


A gunbattle erupted between Malik's forces and the Abu Sayyaf militants Sunday in Patikul's jungles, Freyra said. There were no immediate reports of casualties, and police and the military went on alert amid the fighting.


Sulu Governor Abdusakur Tan has said he will not allow Malik's group to take any drastic action like a rescue that could harm the Abu Sayyaf's hostages.


Atyani was working for the Arabic satellite channel Middle East Broadcasting Corp. when he interviewed Osama bin Laden and his aides in Afghanistan about three months before the Sept. 11, 2001, attacks. He said they told him that the coming weeks would hold "important surprises that will target American and Israeli interests in the world."


He later moved to Dubai-based Al-Arabiya TV as its Asia bureau chief. He traveled to Sulu to work on a documentary about the country's volatile south and possibly interview Abu Sayyaf militants in the impoverished province, Freyra and other officials said.


The other hostages being held by the Abu Sayyaf include the two European men, who were seized from nearby Tawi Tawi province in February last year and are believed to have been taken to Sulu, a Japanese treasure hunter, a Malaysian national and a Filipino resident of Sulu, officials say.


On Friday, Washington renewed a longstanding warning to Americans not to travel to Sulu "due to the high threat of kidnapping ... and violence linked to insurgency and terrorism there."


The Abu Sayyaf, which has about 380 armed fighters in Sulu and nearby islands, is an extremist offshoot of a Muslim rebellion that has been raging in the predominantly Catholic nation's south for decades. The violence has been fueled by abject poverty, corruption, proliferation of illegal weapons and weak law enforcement.


Read More..

Meet the Man Who Designed BlackBerry’s New Phones






When BlackBerry set out to design the phones that would take the company into the next decade, it faced a big challenge. The flagship device of the new BlackBerry 10 platform needed to simultaneously satisfy what today’s customers want in a smartphone while at the same time stay true to the essence of BlackBerry — which, if the company’s market over the last few years is any indication, customers didn’t want.


The man tasked with redesigning BlackBerry phones was Todd Wood, the company’s senior vice president of design. Leading industrial design at BlackBerry since 2006, Wood is a veteran of industrial design, previously doing design work for Nokia and, before that, Nortel. Mashable sat down with Wood this week while he was in town for the BlackBerry 10 launch.






[More from Mashable: Here’s a Mysterious Image From BlackBerry’s Super Bowl Ad]


Wood speaks with the same thoughtfulness of other design leaders, such as Apple’s Jony Ive, but with none of the showiness. He’s been with BlackBerry (formerly Research In Motion) for long enough to see its fortunes rise and fall. As he describes the Z10, you feel that he’s heard enough praise and criticism about BlackBerry’s products that it all just bounces off.


[More from Mashable: Don’t Hold Your Breath for More BlackBerry Tablets]


When I bring up the BlackBerry Storm — the company’s previous (failed) attempt to create a touchscreen phone — Wood doesn’t bristle or even acknowledge the disaster it was. He simply describes certain design elements that a similar to the BlackBerry Z10, BlackBerry’s new flagship phone. And he makes them sound kind of cool.


“There’s still the ‘waterfall’ that was pronounced on Storm — these flowing surfaces,” Wood says as he points to the top and bottom of the Z10, which are ever-so-slightly sloped. “We’ve brought that with the margins [on the Z10], but it’s very subtle. There are some principles that we carry forward, but nothing’s been cut and pasted.”


As CEO Thorsten Heins described at the launch, BlackBerry faced a decision three years ago: adopt someone else’s mobile OS or go it alone. It opted for the latter, acquiring QNX software in 2010 and adapting it to build first the PlayBook, then BlackBerry 10.


Completely switching mobile platforms was risky and extremely challenging, but it was also a huge design opportunity, says Wood.


“We were starting the platform from scratch. We wanted to build on the design DNA [BlackBerry] had, and we wanted to keep certain attributes — the fit to face, fit to hand — the general comfort of the device, the build quality of the device.”


No Home Button


Key decisions about the device itself depended on how the software worked. There’s no home button on the Z10, for example — a user controls basic functions (like switching between apps) via gestures, such as swiping up from the edge of the screen.


Much of the design was influenced by the need for easy, one-handed operation.


“How can you design a system where you could multitask more elegantly?” Wood asks, rhetorically. “It’s not unlike shuffling cards. And we started to realize you can really do that with one hand and one thumb.


“Almost every phone has a UI paradigm of ‘You go home to go somewhere else.’ Here you can flow from app to app.”


Soft Touch Backside


The phone has a semi-rubberized back, a material that BlackBerry refers to as “soft touch.” The company has used it before — in the trim of the latest Bold smartphone, for example. But in the Z10, Wood’s team added a perforated pattern.


“Soft touch is a special coating that we use,” he explains. “It provides grip, and it’s very silky. What we did was add some microtexture to it, which is something that you don’t notice until you pick the phone up and run your hand across it. It’s a nice subtlety.”


Button Shapes


If you’ve ever thought the physical buttons on Samsung’s phones felt cheap, or the iPhone’s too bland, you’ll appreciate RIM’s contoured buttons for volume and media playback. The volume buttons have a slight notch on one side, and the play/pause button has a small upraised piece — all detectable by touch.


“We wanted to keep them really precise and clean,” says Wood. “We sculpted the keys so it’s always really apparent without looking, almost like braille, exactly where you are.”


Font


Wood also played a role in choosing the system font for BlackBerry 10, which is called Slate. Designed by Canadian Rod McDonald (who also designed the font for Maclean’s, one of Canada’s top national news magazines), BlackBerry chose Slate for its legibility, Wood says.


“Slate really works for screen and print, so we decided to adopt it. When you have such a high-res display, you get really accurate letterforms. When you have a really great font design, that improves productivity. You’re not squinting, and letters are not misinterpreted.”


The Q10


Of course, Wood also led the team that designed the Q10, the BlackBerry 10 phone with a physical QWERTY keyboard, coming about a month after the Z10 debuts. Although the Q10 borrows more design DNA from the BlackBerry of old, BB10 afforded some big departures as well.


For starters, the Q10′s keyboard is straight whereas most previous BlackBerry phone keyboards had a curve to them — which even led to the company calling one of its product lines the Curve.


“That is a big change,” Wood says of straightening out the keyboard for the Q10. “It was very logical, but also it signals ‘This is different.’ And there’s no performance tradeoff with it being straight — we’ve measured it.”


Besides being straight, the keyboard is larger than the ones on previous BlackBerry phones.


“What allows us to get that extra size is we’ve replaced the home key, the back key and the send/end keys, since everything in BB10 is controlled by gestures and direct manipulation of the data. Without the curve, each key is the same size, and they’re 3% larger.”


The Red LED


No BlackBerry phone would be complete without the trademark — and at times notorious — blinking red LED that indicates a message is waiting. Wood says the attribute is hard-wired into BlackBerry design at this point and at no point did the company consider ditching it.


“That’s probably the strongest, most iconic element of the DNA we carry forward,” he says. “It’s origins were ‘Let’s save on battery life,’ and it continues today. For us, we call it the spark, or the splat. It’s a hallmark of BlackBerry it makes some people excited, and it makes some people neurotic, but it’s up to end users to manage that.”


How do you like the design of BlackBerry’s new phones? Let us know in the comments.


BONUS: BlackBerry Z10 Review


Click here to view the gallery: BlackBerry Z10 Review


Lead image by Nina Frazier, Mashable


Images by Nina Frazier, Christina Warren and Pete Pachal, Mashable


This story originally published on Mashable here.


Wireless News Headlines – Yahoo! News





Title Post: Meet the Man Who Designed BlackBerry’s New Phones
Url Post: http://www.news.fluser.com/meet-the-man-who-designed-blackberrys-new-phones/
Link To Post : Meet the Man Who Designed BlackBerry’s New Phones
Rating:
100%

based on 99998 ratings.
5 user reviews.
Author: Fluser SeoLink
Thanks for visiting the blog, If any criticism and suggestions please leave a comment




Read More..

Peterson double winner of AP NFL awards


NEW ORLEANS (AP) — Adrian Peterson called it a blessing in disguise.


Strange way to describe career-threatening major knee surgery.


The Minnesota Vikings' star came back better than ever, just missing Eric Dickerson's longstanding rushing record and closing out the season with two of the top NFL awards from The Associated Press: Most Valuable Player and Offensive Player of the Year.


As sort of an added bonus, he beat Peyton Manning for both of them Saturday night.


"My career could have easily been over, just like that," the sensational running back said. "Oh man. The things I've been through throughout my lifetime has made me mentally tough.


" I'm kind of speechless. This is amazing, " he said in accepting his awards, along with five others at the "2nd Annual NFL Honors" show on CBS saluting the NFL's best players, performances and plays from the 2012 season. The awards are based on balloting from a nationwide panel of 50 media members who regularly cover the NFL.


Manning's own sensational recovery, from four neck surgeries, earned him Comeback Player honors.


"This injury was unlike any other," said the only four-time league MVP. "There really was no bar or standard, there were no notes to copy. We were coming up with a rehab plan as we went."


Before sitting out 2011, Manning had never missed a start in his first 13 seasons with Indianapolis. But he was released by the Colts last winter because of his neck issues, signed with Denver and guided the Broncos to the AFC's best record, 13-3.


"Certainly you have double variables of coming off injury, not playing for over year and joining a new team. That certainly added a lot to my plate, so it was hard to really know what to expect," Manning said. "I can't tell you how grateful and thankful I am. I can't tell you how happy I am to be playing the game of football we all love so much."


Also honored were:


—Washington's Robert Griffin III, who beat out a strong crop of quarterbacks for the top offensive rookie award.


— Houston end J.J. Watt, who took Defensive Player of the Year, getting 49 of 50 votes.


Bruce Arians, the first interim coach to win Coach of the Year after leading Indianapolis to a 9-3 record while head man Chuck Pagano was being treated for leukemia. Arians became Arizona's head coach last month.


—Carolina linebacker Luke Kuechly, the league's leader in tackles with 164, who won the top defensive rookie award.


Peterson returned better than ever from the left knee surgery, rushing for 2,097 yards, 9 short of breaking Dickerson's record. He also sparked the Vikings' turnaround from 3-13 to 10-6 and a wild-card playoff berth.


He received 30 1-2 votes to 19 1-2 for Manning.


"I played my heart out, every opportunity I had," Peterson said. "The result of that is not what I wanted, which is being in the Super Bowl game. But I have a couple of good pieces of hardware to bring back and (put) in my statue area. So it feels good."


Was the knee injury the toughest thing he'd ever overcome?


"Losing my brother at 7, seeing him get hit by a car right in front of me, that was the toughest," he said. "But as far as injuries, yes."


New England QB Tom Brady was the last winner of MVP and Offensive Player in 2010.


"Trying to get two or three like Peyton, trying to get to your level," Peterson said of his first MVP award. "But I won't be there to accept it because I'll be winning with my coach, the most important award, the team award, the Super Bowl."


Dickerson predicted Peterson could get back to 2,000 yards.


"I hope he does have a chance to do it again," Dickerson said, adding with a laugh, "but do I want him to break it? No, I do not."


Wearing a burgundy and gold tie in honor of his Redskins, Griffin said his goal is to be ready for the season opener.


"It's truly a blessing to be up there — to be able to stand, first and foremost," said Griffin, who underwent knee surgery last month. He added that next season "you'll see a better Robert Griffin."


Arians moved up from offensive coordinator and helped Indianapolis make the playoffs at 10-6, making him an easy winner in the balloting.


"It's hard to put into words the feelings of this past year," he said. "This was kind of the cherry on the top, whipped cream and everything else you put on top."


Watt swatted the competition as Denver's Von Miller got the only other vote in the most lopsided balloting of all the awards.


"It sets the bar for me," Watt said. He led the NFL with 20 1-2 sacks and also blocked an astounding 16 passes. "I want to go out and do even better. I want to do even bigger things."


___


Online: http://pro32.ap.org/poll and http://twitter.com/AP_NFL


Read More..