Seahawks roll past 49ers in noisy Seattle 42-13

SEATTLE (AP) — Fueled by its deafening home crowd, the Seattle Seahawks locked up their spot in the postseason Sunday night.

They also reinforced the notion no one in the NFC wants to see them when the playoffs begin, even if they are a wild card.

Russell Wilson threw a career-high four touchdown passes to move into second place for most TD passes by a rookie. Marshawn Lynch scored two first-quarter TDs, and the Seahawks blew out the San Francisco 49ers 42-13.

Richard Sherman returned a blocked field goal 90 yards for another touchdown as the Seahawks (10-5) jumped to a 21-0 lead. That only added to an already hyped crowd on a typically cold and rainy December night, with noise echoing off the walls and overhanging roof of CenturyLink Field that might have been heard all the way across Puget Sound.

No one cared about the cold rain. Not with the performance they were seeing on the field. And not with a ticket to the postseason guaranteed thanks to Seattle's first 10-win season since 2007.

"That crowd was crazy. They were great," Seattle coach Pete Carroll said. "And I'm so thrilled we were able to share it with them. They deserve a playoff team and they got it."

Seattle will likely be the No. 5 seed in the NFC. There remains a slight chance of winning the NFC West if the Seahawks beat St. Louis in the season finale and Arizona can upset the 49ers in San Francisco.

The Seahawks, 7-0 at home, delayed San Francisco (10-4-1) from celebrating a division title. They turned Jim Harbaugh's 49th birthday into a miserable evening.

"I think everybody is going to feel the same way that this wasn't good man," Harbaugh said. "Can't feel like you coached well, can't feel like you played well after this one."

Whether home or on the road, the Seahawks are a scary postseason opponent with the way they are playing.

Seattle was the first team since 1950 to score at least 50 points in consecutive weeks thanks to its 58-0 win over Arizona and 50-17 victory against Buffalo. It seemed inconceivable the scoring binge could continue against San Francisco, the best scoring defense in the NFL.

But it did.

Seattle has outscored its last three opponents 150-30.

The 42 points were the most allowed since Harbaugh took over the 49ers, and the most San Francisco yielded since giving up 45 to Atlanta in 2009. It was the perfect way for Carroll to snap a three-game losing streak against his rival.

"It was a lot of points again tonight, and we're just thrilled about it," Carroll said. "Things have just changed. We have changed on offense, and Russell has been a huge part of it and the coaches allowing it to happen. We don't hold ourselves to points because the standard isn't out there for us. We just try to play really good football and see what happens at the end."

Lynch finished with 111 yards on 26 carries, his third straight game against the 49ers topping 100 yards. Wilson wasn't asked to do much — other than throw touchdown passes.

He hit Lynch on a 9-yard TD in the first quarter, Anthony McCoy for a 6-yarder late in the first half, and Doug Baldwin on 4 and 6 yard TDs in the second half.

Wilson has 25 TD passes, one behind Peyton Manning's NFL rookie record of 26. He finished 15 of 21 for 171 yards. His only incompletion in the first half was a deflected pass that Patrick Willis intercepted.

Wilson led Seattle on scoring drives of 9, 12, 13 and 15 plays. He was never threatened by Aldon Smith, who remained stuck on 19 1-2 sacks for the season because of the play of Seattle left tackle Russell Okung.

The Seahawks were 11 of 13 on third-down conversions. Wilson was the clear winner in the matchup of young quarterbacks.

San Francisco's Colin Kaepernick had already proven himself capable of winning on the road with victories in New Orleans and last week in New England. But Seattle is a different beast, widely regarded by players as the loudest venue in the NFL. His inexperience playing in such an environment showed. He was flustered and disorganized at the line of scrimmage, letting the noise from Seattle's fans affect him.

Kaepernick's forgettable night was capped when Sherman stepped in front of his pass for Randy Moss at the back of the end zone on the first play of the fourth quarter for his seventh interception of the season.

Kaepernick was 19 of 36 for 244 yards with an 18-yard TD pass to Delanie Walker with 1:40 left. Frank Gore had just 28 yards on six carries after rushing for a season-high 131 when the teams met in Week 7.

San Francisco played without defensive tackle Justin Smith due to an elbow injury that ended a streak of 185 starts. The 49ers lost tight end Vernon Davis in the first quarter with a concussion sustained when he was knocked off his feet on a huge hit along the sideline from Seattle safety Kam Chancellor that looked legal but drew a penalty for hitting a defenseless receiver.

The injuries kept coming when starting cornerback Tarell Brown was on the ground clutching his right knee early in the second quarter and had to be helped off the field. Brown returned in the second half.

San Francisco wide receiver Mario Manningham went down with a left leg injury early in the third quarter when he was tackled low by Leroy Hill and fumbled.

___

Online: http://pro32.ap.org/poll and http://twitter.com/AP_NFL

Read More..

Well: With Help Here and There, Preserving Independence in Old Age

My 92-year-old aunt, who is cognitively impaired and requires a walker or wheelchair to get around, still lives in her own apartment, where round-the-clock home health aides help her get to and from the bathroom, bathe, dress and undress, and go outside each day for some fresh air. The aides shop, prepare and serve meals, do light housekeeping and make sure she takes her medications on time.

But last month, my aunt’s long-term care insurance ran out, and her meager savings will soon do the same. Then what?

Her daughters, both of whom work to support their families, cannot afford the $150 a day for 24-hour care by a certified home health aide, and my aunt has nothing to sell that could bring in the needed cash. Nor does she yet qualify for Medicaid or have a terminal illness that would justify hospice care, which would be covered by Medicare.

Complicating matters, her daughters long ago promised that they would not put her in a nursing home.

Such dilemmas are increasingly common as people live longer. The number of Americans 65 and older is expected to double to 80 million in the next three decades. People 85 and older are the fastest-growing age group; by 2020, there will be 6.6 million people in that age bracket, when rates of debilitating ailments soar.

Most Americans over 65 will eventually need help with the so-called tasks of daily living — eating, dressing, bathing, shopping and the like. But with family members spread all over the map or unable to be full-time caregivers for other reasons, the need for new and better options will only increase.

When asked, 80 to 90 percent of older people say they want to remain in their own homes as long as possible. Yet remaining in one’s home indefinitely is not always the best choice, even if it is financially feasible. As life draws near a close, many older adults need more care than can be provided safely at home. Simply finding reputable home health aides can be a nightmare, and family members often are forced to fill gaps in even the best caregiving plans.

The challenge is all the more difficult when no one has thought through the options before a serious illness or injury makes it impossible for elders to return home without full-time help.

Many elders living independently need outside help long before they require round-the-clock care. A range of assistance and housing alternatives has rapidly sprung up to meet this demand. Many focus on improving accessibility in the home and access to neighborhood conveniences.

An older person living in the suburbs who can no longer drive may become isolated, lonely and at risk of malnutrition if there is no person or community service to shop for her and take her places. Even stairs are a major obstacle.

Elinor Ginzler, director of the Cahnmann Center for Supportive Services at the Jewish Council for the Aging in Rockville, Md., writes that “the ability to age in place is greatly determined by the physical design and accessibility of a home, as well as community features like the availability of nearby services and amenities, affordable housing and transportation options.”

Organizations like Staying in Place, a nonprofit group of volunteers, helps people age 50 and older in Woodstock, N.Y., and surrounding communities “maintain active, independent, fulfilling lives in their own homes.” For $125 a year (plus $50 for each additional household member over 50), the organization assists with paperwork and technology; free or low-cost transportation; referrals to discounted service workers; information about, and transport to, local classes and cultural and social activities; and recommendations for home health care agencies and personnel.

Other services that are free or low-cost include Meals on Wheels; friendly visiting; shopping services accessed by phone or computer; activities at senior centers; and adult day care centers.

There are also more costly commercial organizations like Home Instead Senior Care, an international network of more than 900 independently owned franchises that provide in-home nonmedical care for elders and support for their caregivers.

The organization sponsored a yearlong online study of 1,631 caregivers, 697 of whom were assisted by paid in-home nonmedical care. The study found that people receiving the additional paid care required 25 percent fewer doctor visits and were more likely to participate in adult day care.

Sadly, many aides are seriously underpaid. Home Instead, for instance, has lobbied to keep home health care aides exempt from minimum wage standards.

Henry Cisneros, former secretary of the United States Department of Housing and Urban Development and editor of the book “Independent for Life: Homes and Neighborhoods for an Aging America,” points out that “Americans are aging in traditional homes, neighborhoods and communities that were designed for yesterday’s demographic realities, not those of today or the future.”

Mr. Cisneros advocates changing our communities so that the elderly can remain in them. “Homes can be retrofitted, new age-appropriate homes built, existing neighborhoods reconnected, and new communities planned,” he wrote. For example, to accommodate declining eyesight, homes can be fitted with brighter bulbs, better lighting locations, easily accessed controls and nighttime guide lights.

Mr. Cisneros sees a pressing need for affordable packages of home modifications and maintenance to make residences more suitable for older people.

“A certified renovation package for aging in place could include roll-under kitchen and bathroom sinks, grab bars, curbless showers, lever faucets and door handles, a zero-step entrance, and wider doors and hallways,” he wrote.

While such changes have a price tag, they may cost a lot less than current care alternatives for the elderly.

Needed changes at the community level include affordable small-scale housing and cluster housing situated in walkable communities with nearby amenities, businesses, health facilities and public transportation.

Borrowing from the design of assisted living facilities, individual dwelling units might be located around a common space that includes dining areas and social rooms.

For elders who want to be near family members yet maintain their independence, so-called accessory dwelling units with their own kitchens and bathrooms are being built near or attached to family homes.

---

How to Know When Home Alone Is No Longer a Good Idea

Paula Spencer Scott, senior editor at Caring.com, recently compiled a guide to help families determine when the time has come to move older relatives from their homes and into a more supportive environment or, alternatively, to bring in a home health aide who can provide assistance. These signs to look for and questions to ask are adapted from Ms. Scott’s recommendations.

¶ Recent accidents or close calls, like a fall, medical scare or minor car accident.

¶ A slow recovery. How well was a recent illness weathered? Did it develop into something serious? Was medical help sought when needed?

¶ Worsening of a chronic health condition. As problems like chronic obstructive pulmonary disease, dementia or congestive heart failure progress, more help will be needed.

¶ Greater difficulty managing the so-called activities of daily living, like dressing, bathing and cooking.

¶ Bodily changes, like obvious weight loss or gain, increased frailty or unpleasant body odor.

¶ A loss of active friendships, including outings with friends, visits with neighbors or participation in religious or other group activities.

¶ Days spent without leaving the house, perhaps because of difficulty driving or a fear of using public transportation.

¶ Is someone checking in regularly? If not, is there a home-safety alarm system, a personal alarm system or a daily calling service in place?

¶ Is someone nearby to assist if there’s a fire, earthquake, flood or other disaster, and does the older resident understand plans for a catastrophe?

¶ Mail in a chaotic state, scattered about and unopened. Are there unpaid overdue bills, surprising thank-you notes from charities, piles of unread magazines?

¶ If an older relative is still driving, go along for a ride and look for failure to fasten the seat belt or heed dashboard warning lights; signs of tension, preoccupation or distraction while driving; damage to the vehicle that may indicate carelessness.

¶ In the kitchen, signs of excess or forgetfulness, like perishables well past their expiration dates.

¶ Favorite appliances are broken but not scheduled for repair.

¶ Signs of fires. Look for charred stove knobs or pot bottoms, potholders with burned edges, a discharged fire extinguisher. Do smoke and carbon monoxide detectors have live batteries?

¶ A once-neat home now cluttered, spills that were not cleaned up, grime coating bathroom and kitchen appliances or an overflowing laundry basket.

¶ Neglected plants or pets.

¶ Signs of neglect outside the home, like broken windows, debris-filled gutters and drains, uncollected rubbish and an overstuffed mailbox.

¶ Ask friends and neighbors whether your family member’s behavior has changed lately.

¶ Ask the person’s doctor whether you should be concerned about the person’s health or safety and whether a home assessment by a social worker or geriatric care manager may be advisable. If you expect resistance from the person, ask the doctor to “prescribe” a professional evaluation.

¶ If you are the primary caregiver, how are you doing? Are you increasingly exhausted, depressed or becoming resentful of the sacrifices you have to make to care for the person?

¶ Consider your older relative’s emotional state. If she is riddled with anxieties or increasingly lonely, then it may be time to make a move for reasons other than health and safety.

Read More..

E-Book Price War Has Yet to Arrive

Thor Swift for The New York Times

A Google e-reader is displayed at a bookstore. Sales of e-books for the devices have slowed this year.

Right about now, just as millions of e-readers and tablets are being slipped under Christmas trees, there was supposed to be a ferocious price war over e-books.

Last spring, the Justice Department sued five major publishers and Apple on e-book price-fixing charges. The case was a major victory for Amazon, and afterward there were widespread expectations — fueled by Amazon — that the price of e-books would plunge.

The most extreme outcome went like this: Digital versions of big books selling for $9.99 or less would give Amazon complete domination over the e-book market. As sales zoomed upward, even greater numbers of consumers would abandon physical books. The major publishers and traditional bookstores were contemplating a future that would pass them by.

But doomsday has not arrived, at least not yet. As four of the publishers have entered into settlements with regulators and revised the way they sell e-books, prices have selectively fallen but not as broadly or drastically as anticipated.

The $10 floor that publishers fought so hard to maintain for popular new novels is largely intact. Amazon, for instance, is selling Michael Connelly’s new mystery, “The Black Box,” for $12.74. New best sellers by David Baldacci and James Patterson cost just over $11.

One big reason for the lack of fireworks is that the triumph of e-books over their physical brethren is not happening quite as fast as forecast.

“The e-book market isn’t growing at the caffeinated level it was,” said Michael Norris, a Simba Information analyst who follows the publishing industry. “Even retailers like Amazon have to be wondering, how far can we go — or should we go — to make our prices lower than the other guys if it’s not helping us with market share?”

Adult e-book sales through August were up 34 percent from 2011, an impressive rate of growth if you forget that sales have doubled every year for the last four years. And there have been more recent signs of a market pausing for breath.

Macmillan, the only publisher that has not settled with the Justice Department, said last week as part of a statement from John Sargent, its chief executive, that “our e-book business has been softer of late, particularly for the last few weeks, even as the number of reading devices continues to grow.” His laconic conclusion: “Interesting.”

Mr. Norris said Simba, which regularly surveys e-book buyers, has been noticing what it calls “commitment to content” issues.

“A lot of these e-book consumers aren’t behaving like lab rats at a feeder bar,” the analyst said. “We have found that at any given time about a third of e-book users haven’t bought a single title in the last 12 months. I have a feeling it is the digital equivalent of the ‘overloaded night stand’ effect; someone isn’t going to buy any more books until they make a dent in reading the ones they have already acquired.”

Another, more counterintuitive possibility is that the 2011 demise of Borders, the second-biggest chain, dealt a surprising blow to the e-book industry. Readers could no longer see what they wanted to go home and order. “The print industry has been aiding and assisting the e-book industry since the beginning,” Mr. Norris said.

It is possible that Amazon, which controls about 60 percent of the e-book market, is merely holding back with price cuts for the right moment.

The next few weeks are when e-book sales traditionally take a big jump, as all those newly received devices are loaded up with content.

Amazon declined to comment beyond saying, “We have lowered prices for customers from the prices publishers set on a broad assortment of Kindle books.” Barnes & Noble declined to comment on its pricing strategy.

The question of the proper price for e-books has shadowed the industry ever since Amazon introduced the Kindle in late 2007 and created the first truly popular portable reading device. Amazon had a natural impulse to build a market and was an aggressive retailer in any case, so it took best sellers that cost $25 in independent bookstores and sold them for $9.99 as e-books. Consumers liked that. E-book adoption soared.

Read More..

Chinese-American Faces Trial in China Over Business Dispute

BEIJING — As his family tells it, Vincent Wu is an industrious Chinese-American immigrant who sold his family’s suburban Los Angeles home to finance the construction of a shopping center in China he thought would allow him to retire early. To the police in Huizhou, a city in the southern province of Guangdong, Mr. Wu, 54, is a Mafia kingpin and illegal casino operator who dispatched his enemies through kidnapping, extortion and violence.

Whether an accurate depiction of Mr. Wu will emerge during a trial that begins Monday in Huizhou is anyone’s guess, although the 98 percent conviction rate enjoyed by Chinese prosecutors suggests that the defendant stands a slim chance of acquittal.

“It’s going to be a tough battle,” one of his lawyers, Wang Shihua, said Friday as he scrambled to sort through the 8,000 pages of evidence that the police had only recently delivered to Mr. Wu’s defense team. “At the very least, it’s going to be a very confrontational trial.”

That confrontation is likely to center on allegations that Mr. Wu was tortured into signing a confession, which is the crux of the case against him. In a deposition released by his lawyers, Mr. Wu says he was beaten while being hung upside down, deprived of food and water for several days and then given stimulants so he could not sleep. In the end, Mr. Wu says, he signed the declaration of guilt that was placed before him. “They pre-wrote everything,” he told his lawyers, according to the deposition. “If I didn’t sign it, they beat me.”

Mr. Wu’s case, human rights groups say, highlights the problems that even American citizens face in China’s flawed and deeply politicized criminal justice system. Although confessions extracted through torture are technically inadmissible in court, legal experts say the police frequently rely on heavy-handed tactics to win the confessions that often form the basis of convictions. “We’d be pleasantly surprised if the judge even allows the allegations of torture to be discussed in the courtroom,” said Roseann Rife, East Asia director for Amnesty International, which has been publicizing his case.

According to his family, powerful former business associates are behind Mr. Wu’s prosecution. They say one of them, Lin Qiang, a former provincial public security official, is seeking to claim his assets following a Chinese court ruling that favored Mr. Wu.

During an earlier entanglement with Mr. Lin in 2002, Mr. Wu says, he was detained by the police for 11 months, but later released after prosecutors decided that there was insufficient evidence to try him. His family said a ruling in February by the Supreme People’s Court vindicated Mr. Wu’s claims and cemented his ownership of the disputed property, a successful fruit market in the city of Foshan.

Mr. Lin could not be reached for comment, and police officials in Huizhou declined to comment. Kenny Wu, one of Mr. Wu’s sons, said in a phone interview that Mr. Lin warned his father that he would prevail in the end. “ ‘I control the laws in mainland China,’ ” Kenny Wu said Mr. Lin told his father. “ ‘Watch me put you back in prison like I did 10 years ago. Even President Obama and God cannot save you.’ ”

Mr. Wu was arrested in June; later that day, 300 police officers raided his still unfinished Lucky Star shopping center, detaining dozens of employees. After the police obtained incriminating statements against Mr. Wu, most of the detainees were released, although 33 other defendants face trial along with him.

American officials seeking to visit him in jail say they have been stymied because Mr. Wu did not use his American passport on his most recent visit to China from Hong Kong, the former British colony that enjoys some autonomy under Chinese law. Because he often drove between Guangdong and Hong Kong, where he lived before immigrating to the United States in 1993, Mr. Wu used his Hong Kong identification card to avoid the hassle of obtaining a Chinese visa for each border crossing, his family said. Under international law, the Chinese can restrict consular access to Mr. Wu based on the identification he used to enter China.

Shi Da contributed research.

Read More..

Facebook’s SnapChat-Style Sexting App Is Called Poke (Seriously)

Oh, well would you look at Facebook, trying to make a Christmas funny with its SnapChat copycat app. It’s called Poke! Get it? Because SnapChat is what the kids are all using for their sexting these days, apparently, and Poke — you know, that once kinda flirty Facebook future that’s now pretty much useless — can kind of do the same thing, and it kind of sounds like some bad sexual pun, too! Funny, Facebook, very funny, and way to admit the dirty little truth behind “poking” that we knew all along.

RELATED: Facebook to Launch Its Own SnapChat as Social-Network Clone Wars Live on

Oh, wait. They’re serious? Oh, yeah: Friday afternoon Facebook released Poke, its rumored iPhone app for the incredible vanishing half-message “that makes it fun and easy to say hello to friends wherever you are.” But don’t get too heavy on the old-school “Poke” comparisons, because the new app can actually send regular messages, photos, or videos, too — but only for short periods of time, because that is apparently what the kids like doing these days, if SnapChat’s huge success is any indication. There’s more of a time-bomb component to Poke, though: users can choose how long someone sees a poke before it ceases to exist forever — so you could sext poke all day long, because that, too, is apparently what the kids like doing these days, if SnapChat’s huge, smashing, sexy success is any indication.

RELATED: The Life and Philosophy of Mark Zuckerberg

Why would anyone use Poke over SnapChat? Well, the Facebook app itself has a much smoother interface than SnapChat, and you can report people behaving badly, and everyone’s already on Facebook, right? Maybe this is the breaking point Justin Bieber could never hit, when something sexy goes from the tween set to actual human beings. We’ll let you know when Poke shows up in our iPhone’s App Store; for now we’re not entirely sure if this is just some bad joke. (Although it is in the iTunes Store, so… we’ll see?)

Social Media News Headlines – Yahoo! News

Title Post: Facebook’s SnapChat-Style Sexting App Is Called Poke (Seriously)
Rating:
100%

based on 99998 ratings.
5 user reviews.
Author: Fluser SeoLink
Thanks for visiting the blog, If any criticism and suggestions please leave a comment

Read More..

Falcons top Lions 31-18 for home-field advantage

DETROIT (AP) — Matt Ryan got what he wanted.

Calvin Johnson was forced to settle for what he could get.

Ryan matched a career high with four touchdown passes, two to Roddy White, to help the Atlanta Falcons beat the Detroit Lions 31-18 Saturday night and earn home-field advantage throughout the NFC playoffs.

"It's great," Ryan said. "Our confidence is high and our experience — good and bad — has helped us. The key is to keep the focus where it's been."

In yet another loss, Johnson had a record-breaking night.

Johnson broke Jerry Rice's NFL single-season yards receiving mark of 1,848. After making the record-breaking catch in the fourth quarter, Johnson jogged over to the sideline and handed the football to his father.

"That was a very special moment," he said.

Johnson also became the only player with 100 yards receiving in eight straight games and the first with 10 receptions in four games in a row in league history. He had 11 receptions for 225 yards, giving him 1,892 this season.

"I've been an NFL fan my whole life, dating back to watching Johnny Unitas and Raymond Berry as a kid, and I've coached in this league for 19 years," Detroit coach Jim Schwartz said. "I've seen a lot of Hall of Famers, but I've never seen a better player than Calvin Johnson.

"He just broke a record set by Jerry Rice, who is arguably the best player in this history of this league."

The Falcons (13-2) pulled away with Ryan's fourth TD pass to wide-open tight end Michael Palmer in the fourth quarter and Matt Bryant's 20-yard field goal with 3:05 left that gave them a 15-point lead.

Ryan was 25 of 32 for 279 yards without a turnover.

The Falcons hope playing at home, potentially throughout the conference playoffs, helps them more than it did after the 2010 and 1980 seasons. The Falcons failed to win a game in either postseason, getting routed by Green Bay two years ago and blowing a double-digit, fourth-quarter lead to Dallas three decades ago.

Atlanta advanced to its only Super Bowl with a win at Minnesota after winning a franchise-record 14 games during the 1998 season.

The Falcons won't have much incentive to match that mark next week at home against Tampa Bay, when they'll have nothing to gain and something to lose if a key player or more gets hurt.

Detroit (4-11) has been relegated to playing for pride this month and that hasn't been going very well.

The Lions, whose seven-game losing streak is the longest skid in the league, haven't struggled this much since the laughingstock of a franchise became the league's first to go 0-16 in 2008.

The Falcons led 21-3 at halftime before letting the Lions pull within five points early in the fourth quarter.

Ryan dashed Detroit's comeback hopes.

Facing intense pressure, he converted a third down in Atlanta territory with a pass to White, picked on rookie cornerback Jonte Green by throwing to Jones to pick up more first downs and found Tony Gonzalez open to convert another third down to set up his fourth TD pass.

"We didn't play well in the third quarter," Atlanta coach Mike Smith said. "Matt made some big throws on that drive."

Stafford was clearly trying to get the ball to Johnson on the next drive and cornerback Asante Samuel figured that out, stepping in front of the receiver for an interception to set up Bryant's field goal.

Atlanta running back Michael Turner was tackled in the end zone, after Detroit turned the ball over on downs, to give the Lions two meaningless points.

Ryan went deep to White for the first score, connecting with him on a 44-yard TD strike with 5:50 left in the first quarter. Ryan threw a short pass to him early in the second quarter and the standout receiver did the rest on a 39-yard sprint down the sideline.

Ryan put his third TD pass where only Julio Jones could catch it a corner of the end zone, and he did on a 16-yard reception that put Atlanta up 21-3.

Detroit didn't give up, a game after being accused of doing just that in a 38-10 loss at Arizona.

Jason Hanson kicked a second field goal late in the first half to make it 21-6.

After Atlanta opened the second half with a three-and-out drive, Mikel Leshoure scored on a 1-yard run midway through the third quarter to pull the Lions with eight points.

Hanson's third field goal made it 21-16.

Stafford finished 37 of 56 for 443 yards with an interception and the Lions say he set an NFL record for the most yards passing in a game without throwing a TD pass.

Detroit dug a big hole because the Falcons scored two TDs off turnovers in the first half.

Defensive end Kroy Biermann forced running Leshoure to fumble, giving the Falcons the ball at their 31 and they took advantage. Ryan's perfectly lofted pass to White's fingertips converted a third-and-1 in a big way, putting the Falcons ahead.

The Lions responded with another drive into Atlanta territory, but stalled and had to settle for Hanson's 34-yard field goal in the final minute of the opening quarter to pull within four points.

Atlanta earned a double-digit lead on the ensuing drive.

Ryan threw a screen pass to his left to White, who got a great block from tight end Gonzalez, and the receiver raced untouched for a score that put the Falcons ahead 14-3.

White finished with eight receptions for 153 yards and two TDs. Jones had seven receptions for 71 yards and a score.

Ryan completed his first 12 attempts and, after his first incomplete pass, he converted a third-and-10 with an 11-yard toss to Jacquizz Rodgers. Two plays later, Ryan matched a season high with a third TD pass on the connection with Jones. Prior to the game, Ryan hadn't started a game with more than 10 consecutive completions, according to STATS LLC. He started 10 for 10 last month against Tampa Bay.

Johnson had three receptions for 70 yards in the first quarter, breaking Herman Moore's single-season franchise record for yards receiving.

By halftime, Johnson had 117 yards receiving. He had 100 yards receiving for an eighth straight game, breaking a record set by Charley Hennigan in 1961 and matched by Michael Irvin in 1995. It was Johnson's 11th game with 100 yards receiving this season, tying Irvin's NFL mark.

"Calvin is one of the best players in the game and I think everybody is a big fan of his," Ryan said. "He's one of the most genuinely nice people you could meet."

Stafford connected with Johnson on a short crossing route and the receiver did the rest, outrunning Falcons on a 49-yard gain. Fittingly, the Lions turned the ball over on the next snap in the latest lowlight in a season full of them.

The Lions, Falcons and fans at Ford Field in Detroit honored the victims of the shootings at Sandy Hook Elementary School before the game. Players had memorial decals on their helmets that read "S.H.E.S." in white on a black background, and Detroit's coaches wore pins with a similar design. There was also a moment of silence before the national anthem while the names and ages of each victim were shown on the videoboards. Twenty children and six adults were killed in the Dec. 14 shooting in Newtown, Conn. Adam Lanza killed his mother, shot students and staff, then killed himself.

NOTES: Stafford, in his fourth season, has 1,090 career completions to surpass Bobby Layne's franchise record of 1,074. Stafford is seven attempts away from surpassing the NFL's single-season mark of 691 set by Drew Bledsoe with New England in 1994. ... Backup Falcons CB Christopher Owens had a hamstring injury.

___

Online: http://pro32.ap.org/poll and http://twitter.com/AP_NFL

___

Follow Larry Lage on Twitter: http://twitter.com/larrylage

Read More..

Genetic Gamble : Drugs Aim to Make Several Types of Cancer Self-Destruct

C.J. Gunther for The New York Times

Dr. Donald Bergstrom is a cancer specialist at Sanofi, one of three companies working on a drug to restore a tendency of damaged cells to self-destruct.

For the first time ever, three pharmaceutical companies are poised to test whether new drugs can work against a wide range of cancers independently of where they originated — breast, prostate, liver, lung. The drugs go after an aberration involving a cancer gene fundamental to tumor growth. Many scientists see this as the beginning of a new genetic age in cancer research.

Great uncertainties remain, but such drugs could mean new treatments for rare, neglected cancers, as well as common ones. Merck, Roche and Sanofi are racing to develop their own versions of a drug they hope will restore a mechanism that normally makes badly damaged cells self-destruct and could potentially be used against half of all cancers.

No pharmaceutical company has ever conducted a major clinical trial of a drug in patients who have many different kinds of cancer, researchers and federal regulators say. “This is a taste of the future in cancer drug development,” said Dr. Otis Webb Brawley, the chief medical and scientific officer of the American Cancer Society. “I expect the organ from which the cancer came from will be less important in the future and the molecular target more important,” he added.

And this has major implications for cancer philanthropy, experts say. Advocacy groups should shift from fund-raising for particular cancers to pushing for research aimed at many kinds of cancer at once, Dr. Brawley said. John Walter, the chief executive officer of the Leukemia and Lymphoma Society, concurred, saying that by pooling forces “our strength can be leveraged.”

At the heart of this search for new cancer drugs are patients like Joe Bellino, who was a post office clerk until his cancer made him too sick to work. Seven years ago, he went into the hospital for hernia surgery, only to learn he had liposarcoma, a rare cancer of fat cells. A large tumor was wrapped around a cord that connects the testicle to the abdomen. “I was shocked,” he said in an interview this summer.

Companies have long ignored liposarcoma, seeing no market for drugs to treat a cancer that strikes so few. But it is ideal for testing Sanofi’s drug because the tumors nearly always have the exact genetic problem the drug was meant to attack — a fusion of two large proteins. If the drug works, it should bring these raging cancers to a halt. Then Sanofi would test the drug on a broad range of cancers with a similar genetic alteration. But if the drug fails against liposarcoma, Sanofi will reluctantly admit defeat.

“For us, this is a go/no-go situation,” said Laurent Debussche, a Sanofi scientist who leads the company’s research on the drug.

The genetic alteration the drug targets has tantalized researchers for decades. Normal healthy cells have a mechanism that tells them to die if their DNA is too badly damaged to repair. Cancer cells have grotesquely damaged DNA, so ordinarily they would self-destruct. A protein known as p53 that Dr. Gary Gilliland of Merck calls the cell’s angel of death normally sets things in motion. But cancer cells disable p53, either directly, with a mutation, or indirectly, by attaching the p53 protein to another cellular protein that blocks it. The dream of cancer researchers has long been to reanimate p53 in cancer cells so they will die on their own.

The p53 story began in earnest about 20 years ago. Excitement ran so high that, in 1993, Science magazine anointed it Molecule of the Year and put it on the cover. An editorial held out the possibility of “a cure of a terrible killer in the not too distant future.”

Companies began chasing a drug to restore p53 in cells where it was disabled by mutations. But while scientists know how to block genes, they have not figured out how to add or restore them. Researchers tried gene therapy, adding good copies of the p53 gene to cancer cells. That did not work.

Then, instead of going after mutated p53 genes, they went after half of cancers that used the alternative route to disable p53, blocking it by attaching it to a protein known as MDM2. When the two proteins stick together, the p53 protein no longer functions. Maybe, researchers thought, they could find a molecule to wedge itself between the two proteins and pry them apart.

The problem was that both proteins are huge and cling tightly to each other. Drug molecules are typically tiny. How could they find one that could separate these two bruisers, like a referee at a boxing match?

In 1996, researchers at Roche noticed a small pocket between the behemoths where a tiny molecule might slip in and pry them apart. It took six years, but Roche found such a molecule and named it Nutlin because the lab was in Nutley, N.J.

But Nutlins did not work as drugs because they were not absorbed into the body.

Roche, Merck and Sanofi persevered, testing thousands of molecules.

At Sanofi, the stubborn scientist leading the way, Dr. Debussche, maintained an obsession with p53 for two decades. Finally, in 2009, his team, together with Shaomeng Wang at the University of Michigan and a biotech company, Ascenta Therapeutics, found a promising compound.

The company tested the drug by pumping it each day into the stomachs of mice with sarcoma.

Read More..

Preoccupations: When Relocation Is a Way of Life

ON New Year’s Day, the company I work for, Four Seasons Hotels and Resorts, will move me from Washington to Paris, where I will become a regional vice president of the company and general manager of the Hotel George V, which it manages.

Daniel Rosenbaum for The New York Times

Gathering the frequent-mover miles: From left are Christian and Meg Clerc, and their daughters, Eleanor and Georgia, at home in Washington.

My wife, Meg, teaches at a Montessori school. She and our teenage daughters, Eleanor and Georgia, will reunite with me at the end of the school year. It’s the seventh move for Meg and me: about every three years for the last two decades, we’ve packed and unpacked, and left newfound schools, friends, cars, dry cleaners, banks and homes, and found newer ones.

If you want to advance in the hotel industry, you’d better be able to check “yes” next to the box that asks, “Willing to relocate?” Mobility must be in your DNA if you want to move up. Originally from Switzerland, I myself have moved eight times over 25 years of working in hotels, rising from hotel restaurant food runner to hotel general manager: from Gstaad to Lausanne, Switzerland; then to Washington, Rome, Paris and back to Washington, then to Puerto Vallarta, Mexico, and to Chicago and Washington once more. Eleanor, now 17, was born in Rome. Georgia, 14, joined the journey on our first assignment in Washington.

Meg knew the score — and welcomed the global lifestyle — when she married me. In fact, she chose a mobile career herself, knowing that there would be Montessori schools worldwide.

The company provides good logistical support when it moves its employees. And on the home front, we have grown increasingly adaptive, and the moves have become easier over the years. The process begins when I first realize that a move may be in the works. Meg and I go out for lunch or coffee and review our trusty to-do list to become move-ready. Then we take our daughters out to lunch or dinner and broach the subject, beginning with “How would you feel if we moved to X?”

The worst reaction was when we planned to move back to Washington from Chicago less than a year after arriving there from Mexico. We thought the girls would be thrilled to reunite with friends in a familiar place. We thought wrong. In unison, they broke out in tears; they had just made new friends and were starting to fit in again.

Meg, so skilled at working with children as a teacher, had them talk about the roots of their fears and sadness, which usually revolve around establishing new social networks. I, racked by guilt about upsetting their cart again, blurted that they could get the puppy they had been begging for. (I had been adamantly opposed until then.) The tears stopped. Needless to say, our pup, Snickers, will be moving to Paris, too.

To stay sane at relocation time, we keep the house we’re in as homey as possible until we move, then turn the new house into a home as fast as we can. That way, we don’t have to stare at cardboard boxes on both ends of the trip. We can pack in two weeks.

Moving makes you prioritize what’s important. You have to decide what’s crucial enough to bring, and what’s marginal enough to leave behind. With friends, you have to choose those to see before you go, and the ones you want to stay in touch with after the move.

Each of us has certain things we take along — our “transitional objects.” For example, I need the big wooden credenza that’s been in my family for generations, a great coffee machine, my A.S. Roma soccer-club shirt and my watch box — after all, I am Swiss. For Meg, it’s not about things, but about creating a cozy, well-lit new space. The girls still bring their favorite stuffed animals along with photos, but their most important transitional object is each other.

BUILDING a new network of friends can be as daunting for Meg and me as it is for the girls. We’ve found friends among new work colleagues and through tight-knit expat communities. But there’s a danger of getting stuck in a cultural bubble and never befriending local people.

Our moves have brought us a great appreciation of cultural differences. The ability to adapt quickly to change helps in all kinds of situations. The moves have also prepared our daughters to make new friends quickly. Still, we wonder and worry how it will affect their future relationships. Will they have trouble forming long-lasting bonds?

We find inspiration, meanwhile, in
the lyrics of “You’re My Home,” the Billy Joel song: “I never had a place that I could call my very own, but that’s
all right, my love, ’cause you’re my home.”

As told to Perry Garfinkel.

Read More..

Ben Ali’s Possessions to Be Auctioned in Tunisia

TUNIS — It could be the Middle East’s most opulent yard sale.

Just in time for Christmas, Tunisia’s Finance Ministry has organized a public auction of cars, jewels, carpets and trinkets that once belonged to the deposed president, Zine el-Abidine Ben Ali, the first autocrat to fall in the Arab Spring revolution incubated here two years ago.

The monthlong sale and exhibition of 12,000 items begins Saturday at the Cleopatra Hotel, a sumptuous property in a northern suburb of Tunis.

For the price of a 30-dinar ticket, about $20, curious Tunisians can gape freely at the former president’s collection of rare clocks, rococo-themed picture frames and gold-plated falcons. Those in a shopping spirit can even take home one of the first lady’s treadmills or handbags.

Advertisements for the event feature a village of mud-brick houses lighted by one of the former president’s sparkling chandeliers and a poster of a smiling schoolboy whose image is Photoshopped into the back seat of Mr. Ben Ali’s Bentley.

According to the event’s French-language Web site, www.confiscation.tn, “bargain hunters” can buy an array of high-end electronics, while those with more “retro” tastes can indulge in one of Mr. Ben Ali’s many knickknacks, some of them gifts from wealthy businessmen and fellow despots.

The government aims to raise an estimated 20 million dinars, about $13 million, from the event, largely through the sale of big-ticket items like Mr. Ben Ali’s fleet of luxury automobiles, more than 300 items of silver and gold jewelry, and an extensive collection of local and foreign artworks.

Thirty-nine of his cars will be up for auction, including two Lamborghini Gallardos and an Aston Martin Vanquish that contains a personalized plate reading “hand-built in England for Sakher el Materi,” Mr. Ben Ali’s son-in-law, now 31.

The items are mostly from Mr. Ben Ali’s Sidi Dhrif residence, one of numerous presidential palaces peppered across Tunisia’s northeast coast. After the Jan. 14, 2011, revolution that sent Mr. Ben Ali and his family into exile in Saudi Arabia, locals destroyed or looted some of the family’s homes, including a sumptuous palace in the Hammamet resort district.

 Attempts to retake public ownership of Mr. Ben Ali’s assets, particularly his foreign holdings, have proceeded fitfully over the past two years.

Many Tunisians have criticized the government as moving too slowly on the sale of confiscated assets and have expressed frustration at the prospect that Mr. Ben Ali could reclaim some of his old possessions through Saudi purchasers.

According to a statement from Slim Besbes, then acting minister of finance, it took eight months just to determine the value of items and legal procedures surrounding the sale of Mr. Ben Ali’s confiscated assets.

While some cars in his collection have been sold in earlier auctions, the event starting Saturday is the government’s most ambitious sell-off effort yet. And even those items represent a small sliver of what the government considers Mr. Ben Ali’s corruptly attained assets, which included 398 holding companies, Tunisian banks and telecommunications concerns.

 

Read More..

Google working on “X Phone”, “X” tablet to take on rivals – WSJ

(Reuters) – Google Inc is working with recently acquired Motorola on a handset codenamed “X-phone”, aimed at grabbing market share from Apple Inc and Samsung Electronics Co Ltd, the Wall Street Journal said, citing people familiar with the matter.

Google acquired Motorola in May for $ 12.5 billion to bolster its patent portfolio as its Android mobile operating system competes with rivals such as Apple and Samsung.

The Journal quoted the people saying that Motorola is working on two fronts: devices that will be sold by carrier partner Verizon Wireless, and on the X phone.

Motorola plans to enhance the X Phone with its recent acquisition of Viewdle, an imaging and gesture-recognition software developer. The new handset is due out sometime next year, the business daily said, citing a person familiar with the plans.

Motorola is also expected to work on an “X” tablet after the phone. Google Chief Executive Larry Page is said to have promised a significant marketing budget for the unit, the newspaper said quoting the persons.

Google was not immediately reachable for comments outside regular U.S. business hours.

(Reporting by Balaji Sridharan in Bangalore; Editing by Richard Chang)

Tech News Headlines – Yahoo! News

Title Post: Google working on “X Phone”, “X” tablet to take on rivals – WSJ
Rating:
100%

based on 99998 ratings.
5 user reviews.
Author: Fluser SeoLink
Thanks for visiting the blog, If any criticism and suggestions please leave a comment

Read More..