Alzheimer’s Precursors Founds at Earlier Age

Scientists studying Alzheimer’s disease are increasingly finding clues that the brain begins to deteriorate years before a person shows symptoms of dementia.

Now, research on a large extended family of 5,000 people in Colombia with a genetically driven form of Alzheimer’s has found evidence that the precursors of the disease begin even earlier than previously thought, and that this early brain deterioration occurs in more ways than has been documented before.

The studies, published this month in the journal Lancet Neurology, found that the brains of people destined to develop Alzheimer’s clearly show changes at least 20 years before they have any cognitive impairment. In the Colombian family, researchers saw these changes in people ages 18 to 26; on average, members of this family develop symptoms of mild cognitive impairment at 45 and of dementia at 53.

These brain changes occur earlier than the first signs of plaques made from a protein called beta amyloid or a-beta, a hallmark of Alzheimer’s. Researchers detected higher-than-normal levels of amyloid in the spinal fluid of these young adults. They found suggestions that memory-encoding parts of the brain were already working harder than in normal brains. And they identified indications that brain areas known to be affected by Alzheimer’s may be smaller than in those who do not have the Alzheimer’s gene.

“This is one of the most important pieces of direct evidence that individual persons have the disease and all the pathology many years before,” said Dr. Kaj Blennow, a professor in clinical neurochemistry at the University of Gothenburg in Sweden, who was not involved in the research.

Dr. Nick Fox, a neurologist at University College London, who was also not part of the research, said the findings suggested that “some of the things that we thought were more downstream may not be quite so downstream; they may be happening earlier.”

That, in turn, said Dr. Fox, who wrote a commentary about the findings in Lancet Neurology, could have implications for when and how to treat people, because “there may be targets to attack, whether it’s high levels of a-beta or whatever, when people are still functioning very well.”

The Colombian family suffers from a rare form of Alzheimer’s that is caused by a genetic mutation; it strikes about a third of its members in midlife. Because the family is so large and researchers can identify who will get the disease, studying the family provides an unusual opportunity to learn about Alzheimer’s causes and pathology.

Researchers, led by Dr. Eric Reiman of the Banner Alzheimer’s Institute in Phoenix, and in Colombia by Dr. Francisco Lopera, a neurologist at the University of Antioquia, recently received a grant from the National Institutes of Health to conduct a clinical trial to test a drug on family members before they develop symptoms, to see if early brain changes can be halted or slowed.

The studies in Lancet Neurology used several tests, including spinal taps, brain imaging and functional M.R.I.

“The prevailing theory has been that development of Alzheimer’s disease begins with the progressive accumulation of amyloid in the brain,” Dr. Reiman said. “This study suggests there are changes that are occurring before amyloid deposition.”

One possibility is that brain areas are already impaired. Another possibility, experts said, is that these brain differences may go back to the young developing brain.

“It is a genetic disease, and it’s not hard to imagine that your gene results in some differences in the way your brain is formed,” said Dr. Adam Fleisher, director of brain imaging at the Banner Institute and an author of the studies.

In one of the Lancet Neurology studies, researchers examined 44 relatives between ages 18 to 26. Twenty had the mutation that causes Alzheimer’s. The cerebrospinal fluid of those with the mutation contained more amyloid than that of relatives without it. This was striking because researchers know that when people develop amyloid plaques — whether they have early-onset or late-onset Alzheimer’s — amyloid levels in their spinal fluid are lower than normal. That is believed to be because the fluid form of amyloid gets absorbed into the plaque form, Dr. Reiman said.

So, the high level of amyloid fluid in the Colombian family supports a hypothesis about a difference between the beginning phases of genetic early-onset Alzheimer’s and the more common late-onset Alzheimer’s. The difference may be that early-onset Alzheimer’s involves an overproduction of amyloid, while late onset involves a problem clearing amyloid from the brain.

In another result, when the subjects performed a task matching names with faces, those with the mutation had greater activity in the hippocampus and parahippocampus, areas involved in memory. Dr. Reiman suggested this could mean that the pre-Alzheimer’s brain has to expend more effort to encode memories than a normal brain.

Researchers also found that the mutation carriers had less gray matter in areas that tend to shrink when people develop dementia. Dr. Fox emphasized that seeing less gray matter so early was so novel that it should be treated cautiously unless other studies find a similar result.

In the second study, brain imaging was used to look for amyloid plaques in 50 people ages 20 to 56: 11 with dementia, 19 mutation carriers without symptoms and 20 normal family members. Plaques occurred at an average age of 28, more than 15 years before cognitive impairment would be expected and two decades before dementia.

The study also found that amyloid plaques increased steadily until about age 37, after which the brain did not seem to gain many more plaques. Dr. Blennow said that while researchers know that amyloid plaques plateau when people already have dementia, they did not know that the plateau appears to occur years before.

The researchers are currently analyzing data from family members ages 7 to 17 to see if some of the brain changes occur at an even younger age.

“Some people think that that may be scary, that you can see it so many years before,” Dr. Reiman said. “But it seems to me that that provides potential opportunities for the development of future therapies.”

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False Posts on Facebook Undermine Its Credibility

SAN FRANCISCO — The Facebook page for Gaston Memorial Hospital, in Gastonia, N.C., offers a chicken salad recipe to encourage healthy eating, tips on avoiding injuries at Zumba class, and pictures of staff members dressed up at Halloween. Typical stuff for a hospital in a small town.

But in October, another Facebook page for the hospital popped up. This one posted denunciations of President Obama and what it derided as “Obamacare.” It swiftly gathered hundreds of followers, and the anti-Obama screeds picked up “likes.” Officials at the hospital, scrambling to get it taken down, turned to their real Facebook page for damage control. “We apologize for any confusion,” they posted on Oct. 8, “and appreciate the support of our followers.”

The fake page came down 11 days later, as mysteriously as it had come up. The hospital says it has no clue who was behind it.

Fakery is all over the Internet. Twitter, which allows pseudonyms, is rife with fake followers, and has been used to spread false rumors, as it was during Hurricane Sandy. False reviews are a constant problem on consumer Web sites.

Gaston Memorial’s experience is an object lesson in the problem of fakery on Facebook. For the world’s largest social network, it is an especially acute problem, because it calls into question its basic premise. Facebook has sought to distinguish itself as a place for real identity on the Web. As the company tells its users: “Facebook is a community where people use their real identities.” It goes on to advise: “The name you use should be your real name as it would be listed on your credit card, student ID, etc.”

Fraudulent “likes” damage the trust of advertisers, who want clicks from real people they can sell to and whom Facebook now relies on to make money. Fakery also can ruin the credibility of search results for the social search engine that Facebook says it is building.

Facebook says it has always taken the problem seriously, and recently stepped up efforts to cull fakes from the site. “It’s pretty much one of the top priorities for the company all the time,” said Joe Sullivan, who is in charge of security at Facebook.

The fakery problem on Facebook comes in many shapes. False profiles are fairly easy to create; hundreds can pop up simultaneously, sometimes with the help of robots, and often they persuade real users into friending them in a bid to spread malware. Fake Facebook friends and likes are sold on the Web like trinkets at a bazaar, directed at those who want to enhance their image. Fake coupons for meals and gadgets can appear on Facebook newsfeeds, aimed at tricking the unwitting into revealing their personal information.

Somewhat more benignly, some college students use fake names in an effort to protect their Facebook content from the eyes of future employers.

Mr. Sullivan declined to say what portion of the company’s now one billion plus users were fake. The company quantified the problem last June, in responding to an inquiry by the Securities and Exchange Commission. At that time, the company said that of its 855 million active users, 8.7 percent, or 83 million, were duplicates, false or “undesirable,” for instance, because they spread spam.

Mr. Sullivan said that since August, the company had put in place a new automated system to purge fake “likes.” The company said it has 150 to 300 staff members to weed out fraud.

Flags are raised if a user sends out hundreds of friend requests at a time, Mr. Sullivan explained, or likes hundreds of pages simultaneously, or most obvious of all, posts a link to a site that is known to contain a virus. Those suspected of being fakes are warned. Depending on what they do on the site, accounts can be suspended.

In October, Facebook announced new partnerships with antivirus companies. Facebook users can now download free or paid antivirus coverage to guard against malware.

“It’s something we have been pretty effective at all along,” Mr. Sullivan said.

Facebook’s new aggressiveness toward fake “likes” became noticeable in September, when brand pages started seeing their fan numbers dip noticeably. An average brand page, Facebook said at the time, would lose less than 1 percent of its fans.

But the thriving market for fakery makes it hard to keep up with the problem. Gaston Memorial, for instance, first detected a fake page in its name in August; three days later, it vanished. The fake page popped up again on Oct. 4, and this time filled up quickly with the loud denunciations of the Obama administration. Dallas P. Wilborn, the hospital’s public relations manager, said her office tried to leave a voice-mail message for Facebook but was disconnected; an e-mail response from the social network ruled that the fake page did not violate its terms of service. The hospital submitted more evidence, saying that the impostor was using its company logo.

Eleven days later, the hospital said, Facebook found in its favor. But by then, the local newspaper, The Gaston Gazette, had written about the matter, and the fake page had disappeared.

Facebook declined to comment on the incident, and pointed only to its general Statement of Rights and Responsibilities.

The election season seems to have increased the fakery.

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The New Islamists: Tunisia Battles Over Pulpits and a Revolution’s Legacy

Moises Saman for The New York Times

Female students at the Grand Mosque in Kairouan, Tunisia, a site of anti-Western sermons.

KAIROUAN, Tunisia — On the Friday after Tunisia’s president fell, Mohamed al-Khelif mounted the pulpit of this city’s historic Grand Mosque to deliver a full-throttle attack on the country’s corrupt culture, to condemn its close ties with the West and to demand that a new constitution implement Shariah, or Islamic law.

Articles in this series are exploring the rise of political Islam in the Middle East, as Islamic movements struggle to remake the Arab world.

Moises Saman for The New York Times

Mohamed al-Khelif, who at the Grand Mosque in Kairouan has attacked Tunisian ties with the West and demanded Islamic law.

“They’ve slaughtered Islam!” thundered Dr. Khelif, whom the ousted government had barred from preaching for 20 years. “Whoever fights Islam and implements Western plans becomes in the eyes of Western politicians a blessed leader and a reformer, even if he was the most criminal leader with the dirtiest hands.”

Mosques across Tunisia blazed with similar sermons that day and, indeed, every Friday since, in what has become the battle of the pulpit, a heated competition to define Tunisia’s religious and political identity.

Revolution freed the country’s estimated 5,000 officially sanctioned mosques from the rigid controls of the previous government, which appointed every prayer leader and issued lists of acceptable topics for their Friday sermons.

That system pushed a moderate, apolitical model of Islam that avoided confronting a dictator. When the system collapsed last year, ultraconservative Salafis seized control of up to 500 mosques by government estimates. The government, a proponent of a more temperate political Islam, says it has since wrested back control of all but 70 of the mosques, but acknowledges it has not yet routed the extremists nor thwarted their agenda.

“Before, the state suffocated religion — they controlled the imams, the sermons, the mosques,” said Sheik Tai’eb al-Ghozzi, the Friday Prayer leader at the Grand Mosque here. “Now everything is out of control — the situation is better but needs control.”

To this day, Salafi clerics like Dr. Khelif, who espouse the most puritanical, most orthodox interpretation of Islam, hammer on favorite themes that include putting Islamic law into effect immediately, veiling women, outlawing alcohol, shunning the West and joining the jihad in Syria. Democracy, they insist, is not compatible with Islam.

“If the majority is ignorant of religious instruction, then they are against God,” said Sheik Khatib al-Idrissi, 60, considered the spiritual guide of all Tunisian Salafis. “If the majority is corrupt, how can we accept them? Truth is in the governance of God.”

The battle for Tunisia’s mosques is one front in a broader struggle, as pockets of extremism take hold across the region. Freshly minted Islamic governments largely triumphed over their often fractious, secular rivals in postrevolutionary elections. But those new governments are locked in fierce, sometimes violent, competition with the more hard-line wing of the Islamic political movements over how much of the faith can mix with democracy, over the very building blocks of religious identity. That competition is especially significant in Tunisia, once the most secular of the Arab nations, with a large educated middle class and close ties to Europe.

The Arab Spring began in Tunisia, and its ability to reconcile faith and governance may well serve as a barometer for the region.

Some analysts link the assertive Tunisian Salafi movement to what they consider a worrying spread of violent extremism across North Africa — including an affiliate of Al Qaeda seizing control of northern Mali; a murderous attack on the American diplomatic mission in Benghazi, Libya; a growing jihadi force facing Israel in the Sinai; and a mob looting an American school and parts of the United States Embassy in Tunis.

Senior government officials said the various groups share an ideology and are in contact with one another, suggesting that while they are scattered and do not coordinate their operations, they reinforce one another’s agendas. There have been several episodes of jihadists caught smuggling small arms from Libya to Mali or Algeria across Tunisia, for example, including two small trucks packed with Kalashnikovs and some manner of shoulder-fired missiles or grenades in June, said Ali Laarayedh, the interior minister.

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10 things you need to know today: November 11, 2012

Emails from Petraeus‘ mistress triggered investigation, the BBC’s chief resigns, and more in our roundup of the stories that are making news and driving opinion

1. BIOGRAPHER’S EMAILS LED FBI TO PETRAEUS AFFAIR
Paula Broadwell, the woman with whom CIA Director David Petraeus had an extramarital affair, leading to his sudden resignation on Friday, had allegedly sent harassing emails to a woman in Florida, leading the FBI to investigate the claim — and eventually uncovering the affair. Broadwell, who was Petraeus‘ official biographer, reportedly sent emails to the Florida woman inquiring about the nature of her relationship with Petraeus, prompting the unidentified woman to lodge a complaint with the FBI. The FBI began its investigation in the spring, and interviewed Petraeus in the past two weeks. During the interview, Petraeus admitted to the affair with Broadwell, who is also married. [Wall Street Journal]
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2. BBC CHIEF RESIGNS OVER GROWING SCANDAL
BBC’s director general George Entwistle resigned his post Saturday night amid growing criticism as the broadcaster deals with an alleged sex abuse scandal that implicated longtime BBC host Jimmy Savile. Savile, who died last year, was suspected of sexually abusing hundreds of young people over the decades, sometimes on BBC premises. Entwistle had most recently come under fire for allowing a false report on the BBC program Newsnight to air on Nov. 2. During the broadcast, a former Conservative Party politician was wrongly implicated in a pedophile scandal involving a children’s home in Wales. Entwistle said the report reflected “unacceptable journalistic standards” and never should have been broadcast. [New York Times]
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SEE ALSO: 10 things you need to know today: November 2, 2012

3. ISRAEL FIRES WARNING SHOT AT SYRIA
Israel fired a warning shot into Syria on Sunday after a stray mortar from Syria hit a military post in the Golan Heights. No injuries or damage were reported in Israel. Israel captured the Golan from Syria in the 1967 Mideast war and subsequently annexed it. The incident was the first time Israel has been drawn into the fighting in the neighboring country. Meanwhile, the Syrian opposition, holding critical meetings in Qatar agreed Saturday to a new coalition to oppose President Bashar al-Assad. One Islamist opposition delegate said a new leader and deputy would be chosen on Sunday evening. [Associated Press, BBC]
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4. REP. ALLEN WEST WON’T CONCEDE
Rep. Allen West (R-Fla.) was defeated by Democratic opponent Patrick Murphy, according to Florida’s vote count on Saturday, but the incumbent refuses to concede. The state issued complete but unofficial results showing Murphy with a lead of 2,442 votes, or 50.4 percent. That’s beyond the half-percent margin needed to trigger an automatic recount. West’s campaign alleges that in St. Lucie County, the only one of the three counties in the district that Murphy won, votes may have been counted twice and have asked to review sign-in books from the polls. West’s only path forward is through the courts. Under state law, he still could contest the election if misconduct or fraud might have changed its result. [Politico]
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SEE ALSO: The woman who named her newborn twins Barack and Mitt

5. IRAQ CANCELS ARMS DEAL WITH RUSSIA
Iraq’s Prime Minister Nouri al-Maliki, has canceled a recently signed $ 4.2 billion arms deal with Russia after suspicions of corruption surfaced. The prime minister’s adviser Ali al-Moussawi did not give any details or context. “We informed Russia about our decision, but we hope to sign a new weapons deal between Iraq and Russia,” al-Moussawi said. [CNN]
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6. BOEHNER TELLS HOUSE GOP TO FALL IN LINE
After the Republican Party’s electoral battering last week, House Speaker John Boehner insisted to House Republicans in a conference call that while they “would continue to staunchly oppose tax rate increases as Congress grapples with the impending fiscal battle, they had to avoid the nasty showdowns that marked so much of the last two years,” writes The New York Times. Many members offered subdued words of support, in contrast to a similar call last year when Boehner tried to persuade members to compromise with Democrats on a deal to extend temporary payroll tax cuts, “only to have them loudly revolt.” Both Boehner and President Obama seem to be keeping open the avenue of negotiation to address the looming fiscal cliff set to hit Jan. 1. [New York Times]
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SEE ALSO: The highest skyscraper climb with a bionic leg

7. APPLE AND HTC SETTLE PATENT DISPUTES
Apple and Taiwanese phonemaker HTC have settled all their outstanding disputes over patents, ending a fight that began in March 2010. The two companies signed a 10-year license agreement that will extend to current and future patents held by one another. HTC’s have been in decline since the second half of 2011, despite having become a major global phone company by aligning itself with Google’s Android platform. [BBC]
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8. STRONG EARTHQUAKE HITS MYANMAR
After a 6.-magnitude earthquake hit northern Myanmar on Sunday, at least 12 people were feared dead. The U.S. Geological Survey said the quake hit near the city of Mandalay, at a depth of just 6.2 miles. The shallow quake was felt in Bangkok, the capital of neighboring Thailand, and several aftershocks followed. [Voice of America]
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SEE ALSO: 10 things you need to know today: November 3, 2012

9. CHINA TO LAUNCH NEXT MANNED CRAFT IN JUNE
A spokesperson for the Chinese space program announced Saturday that China’s next space mission will launch in June 2013. The operation is the second manned mission for the country, which completed its first manned mission — Shenzhou-9 — in June of this year. “They will stay in space for 15 days, operating both automated and manual space dockings with the target orbiter Tiangong-1, conducting scientific experiments in the lab module and giving science lectures to spectators on the Earth,” Niu Hongguang of the Chinese space program said. [Forbes]
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10. JUSTIN BIEBER AND SELENA GOMEZ SPLIT
Singer Justin Bieber, 18, and girlfriend, singer-actor Selena Gomez, 20, have gone their separate ways, a source confirms to the Associated Press. The split happened last week, and the two young stars cite distance and their busy schedules as contributing factors. The two had been dating for a year. [Associated Press] 

SEE ALSO: 10 things you need to know today: October 31, 2012

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Texans knock out Cutler, beat Bears 13-6

CHICAGO (AP) — The Houston Texans kept taking the ball away from the Chicago Bears. Then they took their quarterback out of the game.

Arian Foster finished with 102 yards rushing and a touchdown catch, and the Texans intercepted Jay Cutler twice before knocking him out of the game with a concussion on their way to a 13-6 victory over the Chicago Bears on Sunday night.

In a showdown between two of the NFL's best teams, the Texans (8-1) beat the Bears (7-2) at their own game. They came away with four takeaways against a team with a plus-16 turnover differential and Tim Dobbins delivered the biggest blow when he drove his helmet into Cutler late in the second quarter.

"I think we showed them we can win any game, any situation, any time, any place, tough weather conditions, tough place on the road, a very good football team," defensive end J.J. Watt said. "We won, so say what you want."

Foster was the only reliable offensive weapon on either side, particularly in the first half when he ran for 85 yards and made a sprawling catch for a 2-yard touchdown to put Houston ahead 10-3.

Otherwise, neither team got much going on a soggy night. The Texans did just enough, and now they're tied with Atlanta for the league's best record after the Falcons were upset by New Orleans.

"It's huge for us, we were 7-1 going in, to come out 8-1 in a hostile place, given the weather and the team we were playing, that's a tough group to go against," said Matt Schaub, who threw for just 95 yards and was picked off twice by Tim Jennings.

Andre Johnson, Schaub's top target, had just four catches for 35 yards with Charles Tillman on him. Former Bear Danieal Manning helped set the tone, forcing a fumble by Kellen Davis on Chicago's first play from scrimmage and picking off Cutler later in the first quarter.

Cutler completed just 7 of 14 passes for 40 yards with two interceptions in the first half and was seen in street clothes after the game being driving off on a cart by team officials. Jason Campbell threw for 94 yards in the second half.

"You never want to lose anybody, especially our starting quarterback," receiver Brandon Marshall said. "He is our leader, he is the heart and soul of our offense so we definitely want him to have a quick, speedy recovery. In the meantime, Campbell is more than capable. There was no heads hanged down when Jay was down. There was no complaining. We understand we have a starting quarterback in the backup so we're fortunate to have him. There will be no drop off in our offense."

Marshall managed 107 yards receiving but also dropped a pass in the end zone. Matt Forte never got going, running for 39 yards.

But the biggest sequence came when Cutler got hurt.

The Texans had just gone up 10-3 on a lunging 2-yard touchdown catch by Foster. A scrambling Cutler took a helmet-to-helmet hit from Dobbins after unleashing a pass on third down at midfield late in the first half.

There were offsetting penalties on the play. Cutler got called for an illegal forward pass because he was beyond the line of scrimmage and then got drilled by Dobbins, who was called for unnecessary roughness.

Cutler stayed in and the drive ended with his second interception. Kareem Jackson picked off a pass intended for Marshall in double coverage at the Houston 27.

"It's tough," Campbell said. "That what defenses try to do."

Was it a cheap shot?

"He caught him right under the chin," Campbell answered.

Cutler was in for the final drive of the half, but Campbell started the third quarter, sending a big chill through Soldier Field.

After all, the Bears crumbled last season after Cutler injured his thumb, spoiling a 7-3 start. They went into a tailspin with Caleb Hanie and finished 8-8, costing general manager Jerry Angelo his job. With Campbell now in the mix, the Bears believe they could at least survive, and that theory could be put to the test in a big way with a game at San Francisco next Monday night.

"If I have to play, of course, during the week I will get those practice reps and get the guys used to (me)," Campbell said. "And they will get used to me as a quarterback, until Jay is ready. That's something that we have all week to get ready for. We don't have to work that out during the middle of the game."

Campbell couldn't lead them back in the second half, although there was plenty of blame to go around for that.

Robbie Gould kicked a 24-yard field goal late in the third period, but missed a 48-yarder early in the fourth that would have made it a one-point game. Shayne Graham kicked a 42-yarder for Houston to make it 13-6 with 4:49 left.

"It shows we can win in any environment, in any situation," Watt said. "Our team prevailed and obviously a lot of perseverance."

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Online: http://pro32.ap.org/poll and http://twitter.com/AP_NFL

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Well: Quitting Smoking for Good

Few smokers would claim that it’s easy to quit. The addiction to nicotine is strong and repeatedly reinforced by circumstances that prompt smokers to light up.

Yet the millions who have successfully quit are proof that a smoke-free life is achievable, even by those who have been regular, even heavy, smokers for decades.

Today, 19 percent of American adults smoke, down from more than 42 percent half a century ago, when Luther Terry, the United States surgeon general, formed a committee to produce the first official report on the health effects of smoking. Ever-increasing restrictions on where people can smoke have helped to swell the ranks of former smokers.

Now, however, as we approach the American Cancer Society’s 37th Great American Smokeout on Thursday, the decline in adult smoking has stalled despite the economic downturn and the soaring price of cigarettes.

Currently, 45 million Americans are regular smokers who, if they remain smokers, can on average expect to live 10 fewer years. Half will die of a tobacco-related disease, and many others will suffer for years with smoking-caused illness. Smoking adds $96 billion to the annual cost of medical care in this country, Dr. Nancy A. Rigotti wrote in The Journal of the American Medical Association last month. Even as some adult smokers quit, their ranks are being swelled by the 800,000 teenagers who become regular smokers each year and by young adults who, through advertising and giveaways, are now the prime targets of the tobacco industry.

People ages 18 to 25 now have the nation’s highest smoking rate: 40 percent. I had to hold my breath the other day as dozens of 20-somethings streamed out of art gallery openings and lighted up. Do they not know how easy it is to get hooked on nicotine and how challenging it can be to escape this addiction?

Challenging, yes, but by no means impossible. on the Web you can download a “Guide to Quitting Smoking,” with detailed descriptions of all the tools and tips to help you become an ex-smoker once and for all.

Or consult the new book by Dr. Richard Brunswick, a retired family physician in Northampton, Mass., who says he’s helped hundreds of people escape the clutches of nicotine and smoking. (The printable parts of the book’s provocative title are “Can’t Quit? You Can Stop Smoking.”)

“There is no magic pill or formula for beating back nicotine addiction,” Dr. Brunswick said. “However, with a better understanding of why you smoke and the different tools you can use to control the urge to light up, you can stop being a slave to your cigarettes.”

Addiction and Withdrawal

Nicotine beats a direct path to the brain, where it provides both relaxation and a small energy boost. But few smokers realize that the stress and lethargy they are trying to relieve are a result of nicotine withdrawal, not some underlying distress. Break the addiction, and the ill feelings are likely to dissipate.

Physical withdrawal from nicotine is short-lived. Four days without it and the worst is over, with remaining symptoms gone within a month, Dr. Brunswick said. But emotional and circumstantial tugs to smoke can last much longer.

Depending on when and why you smoke, cues can include needing a break from work, having to focus on a challenging task, drinking coffee or alcohol, being with other people who smoke or in places you associate with smoking, finishing a meal or sexual activity, and feeling depressed or upset.

To break such links, you must first identify them and then replace them with other activities, like taking a walk, chewing sugar-free gum or taking deep breaths. These can help you control cravings until the urge passes.

If you’ve failed at quitting before, try to identify what went wrong and do things differently this time, Dr. Brunswick suggests. Most smokers need several attempts before they can become permanent ex-smokers.

Perhaps most important is to be sure you are serious about quitting; if not, wait until you are. Motivation is half the battle. Also, should you slip and have a cigarette after days or weeks of not smoking, don’t assume you’ve failed and give up. Just go right back to not smoking.

Aids for Quitting

Many if not most smokers need two kinds of assistance to become lasting ex-smokers: psychological support and medicinal aids. Only about 4 percent to 7 percent of people are able to quit smoking on any given attempt without help, the cancer society says.

All 50 states and the District of Columbia have free telephone-based support programs that connect would-be quitters to trained counselors. Together, you can plan a stop-smoking method that suits your smoking pattern and helps you avoid common pitfalls.

Online support groups and Nicotine Anonymous can help as well. To find a group, ask a local hospital or call the cancer society at (800) 227-2345. Consider telling relatives and friends about your intention to quit, and plan to spend time in smoke-free settings.

More than a dozen treatments can help you break the physical addiction to tobacco. Most popular is nicotine replacement therapy, sold both with and without a prescription. The Food and Drug Administration has approved five types: nicotine patches of varying strengths, gums, sprays, inhalers and lozenges that can curb withdrawal symptoms and help you gradually reduce your dependence on nicotine.

Two prescription drugs are also effective: an extended-release form of the antidepressant bupropion (Zyban or Wellbutrin), which reduces nicotine cravings, and varenicline (Chantix), which blocks nicotine receptors in the brain, reducing both the pleasurable effects of smoking and the symptoms of nicotine withdrawal. Combining a nicotine replacement with one of these drugs is often more effective than either approach alone.

Other suggested techniques, like hypnosis and acupuncture, have helped some people quit but lack strong proof of their effectiveness. Tobacco lozenges and pouches and nicotine lollipops and lip balms lack evidence as quitting aids, and no clinical trials have been published showing that electronic cigarettes can help people quit.

The cancer society suggests picking a “quit day”; ridding your home, car and workplace of smoking paraphernalia; choosing a stop-smoking plan, and stocking up on whatever aids you may need.

On the chosen day, keep active; drink lots of water and juices; use a nicotine replacement; change your routine if possible; and avoid alcohol, situations you associate with smoking and people who are smoking.

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Some Parents, Shouldering Student Loans, Fall on Tough Times

Gretchen Ertl for The New York Times

“Jenni feels the guilt and I feel the burden.” Michele Fitzgerald, in debt for the loans she took out for her daughter Jenni’s college education.

When Michele Fitzgerald and her daughter, Jenni, go out for dinner, Jenni pays. When they get haircuts, Jenni pays. When they buy groceries, Jenni pays.

It has been six years since Ms. Fitzgerald — broke, unemployed and in default on the $18,000 in loans she took out for Jenni’s college education — became a boomerang mom, moving into her daughter’s townhouse apartment in Hingham, Mass.

Jenni pays the rent.

For Jenni, 35, the student loans and the education they bought have worked out: she has a good job in public relations and is paying down the loans in her name. But for her mother, 60, the parental debt has been disastrous.

“It’s not easy,” Ms. Fitzgerald said. “Jenni feels the guilt and I feel the burden.”

There are record numbers of student borrowers in financial distress, according to federal data. But millions of parents who have taken out loans to pay for their children’s college education make up a less visible generation in debt. For the most part, these parents did well enough through midlife to take on sizable loans, but some have since fallen on tough times because of the recession, health problems, job loss or lives that took a sudden hard turn.

And unlike the angry students who have recently taken to the streets to protest their indebtedness, most of these parents are too ashamed to draw attention to themselves.

“You don’t want your children, much less your neighbors and friends, knowing that even though you’re living in a nice house, and you’ve been able to hold onto your job, your retirement money’s gone, you can’t pay your debts,” said a woman in Connecticut who took out $57,000 in federal loans. Between tough times at work and a divorce, she is now teetering on default.

In the first three months of this year, the number of borrowers of student loans age 60 and older was 2.2 million, a figure that has tripled since 2005. That makes them the fastest-growing age group for college debt. All told, those borrowers owed $43 billion, up from $8 billion seven years ago, according to the Federal Reserve Bank of New York.

Almost 10 percent of the borrowers over 60 were at least 90 days delinquent on their payments during the first quarter of 2012, compared with 6 percent in 2005. And more and more of those with unpaid federal student debt are losing a portion of their Social Security benefits to the government — nearly 119,000 through September, compared with 60,000 for all of 2007 and 23,996 in 2001, according to the Treasury Department’s Financial Management Service.

The federal government does not track how many of these older borrowers were taking out loans for their own education rather than for that of their children. But financial analysts say that loans for children are the likely source of almost all the debt. Even adjusted for inflation, so-called Parent PLUS loans — one piece of the pie for parents of all ages — have more than doubled to $10.4 billion since 2000. Colleges often encourage parents to get Parent PLUS loans, to make it possible for their children to enroll. But many borrow more than they can afford to pay back — and discover, too late, that the flexibility of income-based repayment is available only to student borrowers.

Many families with good credit turn to private student loans, with parents co-signing for their children. But those private loans also offer little flexibility in repayment.

The consequences of such debt can be dire because borrowers over 60 have less time — and fewer opportunities — than younger borrowers to get their financial lives back on track. Some, like Ms. Fitzgerald, are forced to move in with their children. Others face an unexpectedly pinched retirement. Still others have gone into bankruptcy, after using all their assets to try to pay the student debt, which is difficult to discharge under any circumstances.

The anguish over college debt has put a severe strain on many family relationships. Parents and students alike say parental debt can be the uncomfortable, unmentionable elephant in the room. Many parents feel they have not fulfilled a basic obligation, while others quietly resent that their children’s education has landed the family in such difficult territory.

Soon after borrowing the money for Jenni’s education, Ms. Fitzgerald divorced and lost her corporate job. She worked part-time jobs and subsisted on food stamps and public assistance.

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Changing of the Guard: Chinese Communist Party Faces Calls for Democracy

BEIJING — As the Communist Party’s 18th Congress approached, Li Weidong, a scholar of politics, made plans to observe a historic leadership battle in one of the world’s great nations.

Instead of staying in Beijing to monitor China’s once-a-decade transfer of power, Mr. Li boarded a plane.

“I’m going to the United States to study the elections,” Mr. Li said in a telephone interview during a stopover in Paris. After witnessing the American presidential election on Tuesday, Mr. Li went on the radio for another interview. “I still think China’s politics remain prehistoric,” he said. “I often joke that the Chinese civilization is the last prehistoric civilization left in the world.”

With China at a critical juncture, there is a rising chorus within the elite expressing doubt that the 91-year-old Communist Party’s authoritarian system can deal with the stresses bearing down on the nation and its 1.3 billion people. Policies introduced after 1978 by Deng Xiaoping lifted hundreds of millions out of poverty and transformed the country into the world’s second-largest economy. But the way party leaders have managed decades of growth has created towering problems that critics say can no longer be avoided.

Many of those critics have benefited from China’s stunning economic gains, and their ranks include billionaires, intellectuals and children of the party’s revolutionary founders. But they say the party’s agenda, as it stands today, is not visionary enough to set China on the path to stability. What is needed, they say, is a comprehensive strategy to gradually extricate the Communist Party, which has more than 80 million members, from its heavy-handed control of the economy, the courts, the news media, the military, educational institutions, civic life and just the plain day-to-day affairs of citizens.

Only then, the critics argue, can the government start to address the array of issues facing China, including rampant corruption, environmental degradation, and an aging population whose demographics have been skewed because of the one-child policy.

“In order to build a real market economy, we have to have real political reform,” said Yang Jisheng, a veteran journalist and a leading historian of the Mao era. “In the next years, we should have a constitutional democracy plus a market economy.”

For now, however, party leaders have given no indication that they intend to curb their role in government in a meaningful way.

“We will never copy a Western political system,” Hu Jintao, the departing party chief, said in a speech on Thursday opening the weeklong congress.

The party’s public agenda, which Mr. Hu described in detail in his 100-minute address, was laid out in a 64-page report that is in part intended to highlight priorities for the new leaders, who will be announced later this month. Much of the document had retrograde language that emphasized ideology stretching back to Mao and had little in the way of bold or creative thinking, said Qian Gang, the director of the China Media Project at the University of Hong Kong.

Most telling, there was no language signaling that the incoming Politburo Standing Committee, the group that rules China by consensus, would support major changes in the political system, whose perversions many now say are driving the nation toward crisis.

While Chinese who are critical of the current system generally do not expect a wholesale adoption of a Western model, they do favor at least an openness to bolder experimentation.

“To break one-party rule right now is probably not realistic, but we can have factions within the party made public and legalized, so they can campaign against each other,” said Mr. Yang, who added that there was no other way at the moment to ensure political accountability.

Only in the last few years has the idea of liberalizing the political system gained currency, and urgency, among a broad cross-section of elites. Before that, as the West foundered at the onset of the global financial crisis, many here pointed to the triumph of a “China model” or “Beijing consensus” — a mix of authoritarian politics, a command economy and quasi-market policies.

But the way in which China weathered the crisis — with the injection of $588 billion of stimulus money into the economy and an explosion of lending from state banks — led to a spate of large infrastructure projects that may never justify their cost. As a result, many economists now say that China’s investment-driven, export-oriented economic model is unsustainable and needs to shift toward greater reliance on Chinese consumers.

Constant lip-service is paid to that goal, and on Saturday, Zhang Ping, a senior official, reiterated that stance. But it will not be easy for the new leaders to carry it out. At the root of the current economic model is the political system, in which party officials and state-owned enterprises work closely together, reaping enormous profits from the party’s control of the economy. Under Mr. Hu’s decade-long tenure, these relationships and the dominance of state enterprises have only strengthened.

“What happens in this kind of economy is that wealth concentrates where power is,” said Mr. Yang, the journalist.

The 400 or so incoming members of the party’s Central Committee, Politburo and Politburo Standing Committee, as well as their friends and families, have close ties to the most powerful of China’s 145,000 state-owned enterprises. The growing presence of princelings — the children of notable Communist officials — in the party, the government and corporations could mean an even more closely meshed web of nepotism. It is a system that Xi Jinping, anointed to be the next party chief and president and himself a member of the “red nobility,” would find hard to unravel, even if he wanted to.

Mia Li contributed research.

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Are Twitter’s Sports Trolls Out of Control?

The Los Angeles Lakers — a star-stacked superteam with four potential Hall of Famers — have struggled out of the gate this NBA season, and many have placed the blame squarely on new head coach Mike Brown, who was fired on Friday after just five games. Fan frustration, however, reached an ugly crescendo earlier this week, with sports trolls using Twitter to threaten Brown’s teenage son, according to an Orange County Register report.

That’s just the latest in a seemingly increasing series of harassments and even death threats against sports figures. When NFL player Kyle Wilson was hit with death threats in January, the incident was perceived as — if not unprecedented — novel and shocking. Since then, reports of players being threatened on Twitter have become more and more common. Sportscaster Erin Andrews was a high profile victim less than three weeks ago, and posted this response:

[More from Mashable: Twitter Hacked? Here’s How to Protect Your Account]

The growing frequency and severity of sports trolling has raised a number of relevant questions: Have Twitter’s sports trolls gone too far? Can anything be done about them? And, if not, what are the consequences?

A Spiraling Culture of Abuse

Bill Voth, whose company Spiracle Media helps with social media for a number of colleges as well as NBA star Stephen Curry and Olympic gold medalist Ricky Berens, says he’s seen a rise in venomous, execrable behavior by fans on Twitter. He also believes it could eventually lead athletes and celebrities — who played an integral role in raising the microblogging network to its current omnipresence and popularity — to migrate away.

“It just seems like it’s every week now, and it’s gone from just small trolling to threats of physical harm,” he told Mashable. “Trolls are getting louder and more powerful, and I think ultimately this is one of the biggest threats to Twitter itself.”

In addition to physical threats, players regularly receive racial abuse and overly harsh criticism after injuries or disappointing performances. According to Voth, Curry was inundated with “dozens” of messages, many of them vulgar, each day while dealing with nagging ankle problems that forced him out of fantasy basketball lineups last season.

“This sounds cheesy, but these athletes and celebrities are humans too,” Voth says. “When you keep picking at them and sending them messages that they suck, it could get out of hand and eventually affect Twitter’s business model.”

There’s also the question of what would happen if crazed but, by all appearances, delusional and harmless online troll actually carried out a tweeted threat of physical harm. That would obviously raise the stakes and attention paid to harassment, but likely not have any direct effect on Twitter, according to Bradley Shear, an attorney who specializes in social media issues.

“It would be very difficult to hold Twitter and/or any other social media liable for death threats made on their platform,” Shear told Mashable in an email. “However, under the right set of facts, it is conceivable that a digital platform would be liable if they knew or should have known about a potential danger and they did not properly warn others.”

Anti-Troll Legislation

A Twitter spokesperson pointed to the company’s terms of abusive behavior and law enforcement guidelines, but also emphasized the notion that social media doesn’t motivate people to express feelings they don’t already have. The company says it follows up on every reported case of abuse, and works to facilitate law enforcement investigations when applicable. Twitter, however, has also long been vocal about its stance on not moderating content.

While it may seem repulsive in the United States, where freedom of speech is a sacred trope of national identity, trolls who harass athletes in England can be prosecuted and land in jail. In one high-profile case this summer, British diver Tom Daley outed a hateful abuser during the Olympics, and the troll was later arrested. In March a racist Twitter troll was sentenced to 56 days in jail.

Voth, for one, doesn’t rule out the possibility that similar legislation could eventually be a necessity stateside.

“It’s gone from bad to worse in just a year or two, so what’s it going to be like in another year or two?” he says. “Is this something where we need to pass laws against trolls?”

Do you think sports trolls — or Twitter trolls in general — are out of control, or just an unfortunate reality that can’t be dealt with? How would you like to see the issue addressed, either by Twitter or legally?

BONUS GALLERY: Our Favorite Sports Social Media Moments of 2012

1. Devin McCourty Tweets While Playing in the Super Bowl (Sort of)

As New England Patriot Devin McCourty took on the New York Giants in Super Bowl XLVI, his followers were still able to receive real-time updates from his social feeds. But he wasn’t sneaking tweets between plays or during timeouts. Devin and twin brother Jason, who plays for the Tennessee Titans, share their Twitter and Facebook accounts. The Super Bowl showcased one of the more creative approaches to social media in the sports world.

Image courtesy of Devin and Jason McCourty’s Instagram.

Click here to view this gallery.

Thumbnail image credit: Mashable composite, iStockphoto asiseeit

This story originally published on Mashable here.

Social Media News Headlines – Yahoo! News

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Manziel, No. 15 Texas A&M stun No. 1 Bama, 29-24

TUSCALOOSA, Ala. (AP) — Johnny Football and Southern Conference newbies Texas A&M took down the biggest bully in their new neighborhood and left No. 1 Alabama with badly bruised national championship hopes.

Johnny Manziel, better known around Texas as Johnny Football, staked the 15th-ranked Aggies to a three-touchdown lead in the first quarter, and Texas A&M held on to beat the Crimson Tide 29-24 on Saturday.

The Aggies (8-2, 5-2), playing in the SEC for the first season after ditching the Big 12, also might have ended the league's run of BCS titles at six years.

The defending national champion Crimson Tide (9-1, 6-1), who have been No. 1 almost all season, didn't go quietly.

AJ McCarron nearly pulled off a second straight scintillating comeback. He threw one touchdown pass and motored the ball downfield before Deshazor Everett stepped in front of his fourth-down pass at the goal line with 1:36 left.

Manziel passed for 253 yards and rushed for 92 and led the Aggies to a 20-0 first quarter lead.

"No moment is too big for him," coach Kevin Sumlin said of his remarkable redshirt freshman.

The Aggies had been 1-10 against top-ranked teams with the only previous win coming 30-26 over Oklahoma in 2002, but Manziel and Sumlin have entered the SEC with speed and swagger — and fit right in.

Alabama managed a second-shot national title after losing to LSU just over a year ago in the regular season but seems a longshot to do it again. Alabama would have secured a spot in the SEC championship game with a victory and only Western Carolina and Auburn remaining.

"Two of the three national championship teams that I coached lost a game," Tide coach Nick Saban said, counting one at LSU. "This team still has an opportunity to win the West and go to the SEC championship game and win a championship. There's still a lot for this team to play for."

Now, the Tide will have to beat the Tigers to clinch the West and get into the SEC title game. As for the national title, Alabama will have to hope for another shakeup in the form of losses by Kansas State, Oregon and Notre Dame. If the Tide wins out, and two of those teams go down, a third national championship in four seasons is still in play — along with a seventh straight for the SEC.

For now though, the SEC is on the outside looking in at the BCS title race.

Alabama kept coming back, but never caught up with Manziel and Texas A&M.

The nation's top scoring defense, forced a punt with less than a minute left, but A&M never had to kick it away. The Tide was penalized for offisides, giving Texas A&M a first down and a chance to kneel out the clock.

McCarron breathed life into Alabama with a 54-yard touchdown pass down the left sideline to freshman Amari Cooper to make it 29-24 with 4:29 left.

A quick three-and-out by the Aggies put the ball in McCarron's hands again. He opened at the 40 with a 54-yarder to speedster Kenny Bell down to the 6. Two scrambles and an Eddy Lacy run left one final shot from the 2 against a Texas A&M defense often overshadowed by its potent offense.

He had some time on third down, rolling left but finding Lacy well covered and having to try running it, a la Manziel, before Dustin Harris stopped him at the 2.

McCarron had rescued the Tide's national title hopes with a 28-yard screen pass in the final minute for a 21-17 win over No. 9 LSU. The Aggies, nearly two-touchdown underdogs, didn't let him do it again. Everett made the play on a pass toward the front corner of the end zone.

McCarron completed 21 of 34 passes for 309 yard but also was intercepted twice, ending his streak without getting picked off at 291 passes.

Eddie Lacy had 16 carries for 92 yards for Auburn and added 35 yards on four catches. Cooper had six catches for 136 yards a week after missing much the second half of the LSU game with an ankle injury, and failing to make a reception.

The Aggies had already lost to top-10 teams LSU and Florida by a combined eight points, proving they're already challengers in the powerhouse SEC.

Manziel completed 24 of 31 passes with two touchdowns and ran 18 times, including four sacks.

He kept finding Ryan Swope. They hooked up 11 times for 111 yards and a 10-yard touchdown where Manziel bobbled the ball as defenders swarmed him, reversed field and spotted Swope alone in the back of the end zone.

Manziel led three first-quarter touchdown drives for a 20-0 lead to stun the Bryant-Denny Stadium crowd of 101,821. Christine Michael had a pair of 1-yard touchdown runs in the quarter along with Swope's catch.

The rest of the game was an emotional roller-coaster ride for fans who might have thought LSU was the toughest test on the road to another championship.

Then Alabama flexed its own muscle to counter Manziel's speed, sticking with power runs to set up 2-yard touchdown runs by T.J. Yeldon and Lacy.

McCarron also converted a fourth-and-4 with a pass to Lacy to set up the first score. Alabama marched back down the field after C.J. Mosley pushed Manziel out of bounds a yard shy on fourth-and-6.

The Tide ran out all but 19 seconds with a methodical drive right back into the game.

It was still the first time Alabama had trailed at halftime since a loss at South Carolina in 2010.

Jeremy Shelley kicked a 28-yard field goal with 4:49 in the third quarter to cut it to 20-17 and Taylor Bertolet answered with a short one to start the fourth.

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